The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
An assessment of the fibrogenic potential of very short 4T30 chrysotile by intratracheal instillation in rats
Abstract
Three groups of five rats each received, respectively, a single intratracheal instillation of saline (control), 5 mg of UICC chrysotile B asbestos, and 5 mg of a preparation of very short chrysotile fibers (4T30, 100% less than 8 micron) isolated by a sedimentation procedure. At various intervals after the treatment (1 to 60 days), assessment of lung morphology was performed on each animal. Although the two types of chrysotile fibers have similar chemical composition, structure, and surface charge, the lung tissue reaction differed considerably. Lungs of animals exposed to UICC chrysotile B showed significant pathological alterations as early as 7 days following treatment. The lesions were localized in and around terminal bronchioles and consisted of inflammatory cells, fibroblasts and collagen deposition which distorted and obstructed small airways. Reaction to very short 4T30 chrysotile fibers was quite distinct. Seven days after treatment, lungs of these animals showed alveolar and interstitial accumulation of inflammatory cells. The alveolitis persisted 60 days after treatment and no fibrosis was apparent. It appears that very short 4T30 chrysotile fibers are much less fibrogenic than UICC chrysotile B and that intratracheal instillations in rats may represent a useful mean of rapidly assessing the fibrogenic potential of various dusts. These observations support the concept that fiber length is an important factor for fibrogenicity of asbestos.
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In the citing paper
“According to the available data, 58% of fibers had a length < 5 μm and 98% were < 3 μm, for UICC and 4 T30 respectively.”
From Quantification of short and long asbestos fibers to assess asbestos exposure: A review of fiber size toxicity (2014) · cites this paper as [67]
In the citing paper
“These results support the role of fiber length as a critical factor, but they do not suggest the absence of the fibrotic potential of SAF at higher and/or longer exposures.”
From Quantification of short and long asbestos fibers to assess asbestos exposure: A review of fiber size toxicity (2014) · cites this paper as [67]
In the citing paper
“Lemaire et al. [67] also highlighted the varying fibrotic potential of asbestos samples, depending on the fiber length.”
From Quantification of short and long asbestos fibers to assess asbestos exposure: A review of fiber size toxicity (2014) · cites this paper as [67]
In the citing paper
“Within two months of exposure, changes were minimal with the sample of 4 T30 short fibers, and without fibrotic lesions, whereas severe fibrosis in the terminal bronchioles was observed with UICC fibers, highlighting their fast action.”
From Quantification of short and long asbestos fibers to assess asbestos exposure: A review of fiber size toxicity (2014) · cites this paper as [67]
Citations
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Davis, J. M., BECKETT, S. T., Bolton, R., Collings, P., & Middleton, A. (1978) · British Journal of Cancer · doi:10.1038/bjc.1978.105 · Cited by 210
Mineral Fibers: Chemical, Physicochemical, and Biological Properties
Harington, J. S., ALLISON, A. C., & Badami, D. V. (1975) · Advances in pharmacology · doi:10.1016/s1054-3589(08)60223-9 · Cited by 162
EXPERIMENTAL STUDIES OF ASBESTOSIS
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EXPERIMENTAL ASBESTOSIS WITH FOUR TYPES OF FIBERS: IMPORTANCE OF SMALL PARTICLES
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- Holt, 1963, Experimental asbestosis in guinea pigs, Vol. 2, 667
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Cited by
Mechanisms in the Pathogenesis of Asbestosis and Silicosis
MOSSMAN, B. T., & CHURG, A. (1998) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.157.5.9707141 · Cited by 971
Boulanger, G., Andujar, P., Pairon, J.-C., Billon-Galland, M.-A., Dion, C., Dumortier, P., Brochard, P., Sobaszek, A., Bartsch, P., Paris, C., et al. (2014) · Environmental Health · doi:10.1186/1476-069x-13-59 · Cited by 176
Tomatis, M., Turci, F., Ceschino, R., Riganti, C., Gazzano, E., Martra, G., Ghigo, D., & Fubini, B. (2010) · Inhalation Toxicology · doi:10.3109/08958378.2010.504243 · Cited by 53
Ilgren, E., & Chatfield, E. (1997) · Indoor and Built Environment · doi:10.1177/1420326x9700600503 · Cited by 27
Metadata
- Authors
- Lemaire, I., Nadeau, D., Dunnigan, J., & Massé, S.
- Venue
- Environmental Research
- Publisher
- Elsevier BV
- Published
- 1985-04
- Volume
- 36
- Issue
- 2
- Pages
- 314-326
- ISSN
- 0013-9351
- Cited by
- 32
- References
- 23
- Language
- en
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
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- CoChat. (2026). Citation check: An assessment of the fibrogenic potential of very short 4T30 chrysotile by intratracheal instillation in rats. https://app.cochat.ai/papers/10.1016/0013-9351(85)90027-1
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- Lemaire, I., Nadeau, D., Dunnigan, J., & Massé, S. (1985). An assessment of the fibrogenic potential of very short 4T30 chrysotile by intratracheal instillation in rats. Environmental Research. https://doi.org/10.1016/0013-9351(85)90027-1
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