The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Positive chronotropic and inotropic effects of angiotension II in the dog heart
Abstract
The effects of angiotensin II on sinus rate and atrial contractility were investigated in 17 isolated canine atria and 5 isolated paced ventricular preparations perfused with arterial blood conducted from a heparinized donor dog. When angiotensin II was injected into the cannulated sinus node artery, positive chronotropic responses were dose-dependently produced starting from the 0.01 microgram dose although inotropic responses to angiotensin II were not consistently induced. Angiotensin II produced a similar inotropic response pattern in the paced ventricular preparation. Moreover, when angiotensin II was given into the jugular vein of the donor dog, similar positive chronotropic and inotropic responses were also shown in the isolated atrium. Angiotensin II-induced positive chronotropic and slight inotropic effects were not influenced by treatment with the beta-adrenoceptor blocking agents, propranolol and carteolol, but significantly suppressed by saralasin which has been reported to be a competitive antagonist of angiotensin II. From these results, it is suggested that angiotensin II induced a positive chronotropic and slight positive inotropic effect via angiotensin II receptors in the dog heart.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Angiotensin II-induced positive chronotropic and slight positive inotropic effects were demonstrated in the isolated dog heart (Kobayashi et al., 1978).”
From Thoroughly Calibrated Modular Agent-Based Model of the Human Cardiovascular and Renal Systems for Blood Pressure Regulation in Health and Disease (2021) · cites this paper as Kobayashi et al., 1978
Citations
Cites
The action of peptides on the adrenal medulla. Release of adrenaline by bradykinin and angiotensin
Feldberg, W. S., & Lewis, G. P. (1964) · The Journal of Physiology · doi:10.1113/jphysiol.1964.sp007364 · Cited by 359
Myocardial Actions of Angiotensin
Koch‐Weser, J. (1964) · Circulation Research · doi:10.1161/01.res.14.4.337 · Cited by 135
Chiba, S., Yabuuchi, Y., & Hashimoto, K. (1975) · The Japanese Journal of Pharmacology · doi:10.1254/jjp.25.433 · Cited by 101
Self-citationChiba, S. (1976) · European Journal of Pharmacology · doi:10.1016/0014-2999(76)90056-x · Cited by 73
Self-citationYabuuchi, Y., & KINOSHITA, D. (1974) · The Japanese Journal of Pharmacology · doi:10.1254/jjp.24.853 · Cited by 69
STIMULATION OF THE CAT STELLATE GANGLION BY ANGIOTENSIN
Aiken, J. W., & Reit, E. (1968) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)27845-4 · Cited by 54
The Effect of Angiotensin on Myocardial Contractility
Ahmed, S., Levinson, G. E., Weisse, A. B., & Regan, T. J. (1975) · The Journal of Clinical Pharmacology · doi:10.1002/j.1552-4604.1975.tb01449.x · Cited by 27
Absence of direct chronotropic action of angiotensin infused into the sinus node artery
James, T. N. (1965) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1965.209.3.571 · Cited by 25
Hashimoto, K., Kubota, K., Chiba, S., & Taira, N. (1972) · Cellular and Molecular Life Sciences · doi:10.1007/bf01923153 · Cited by 19
Self-citationHashimoto, K., Kimura, T., & Yabuuchi, Y. (1976) · The Japanese Journal of Pharmacology · doi:10.1254/jjp.26.504 · Cited by 16
Research works printed but not linked: 1
- Farr, 1967, Sympathetically mediated effects of angiotensin on the dog heart and in situ, J. Pharmacol. Exptl. Therap., 156], 528
Cited by
Items 101–133 of 133
Roffe, C., MacDiarmaid-Gordon, A. R., Ohanian, V., Hollis, S., & Heagerty, A. M. (1996) · Cardiovascular Research · doi:10.1016/0008-6363(96)00045-4 · Cited by 4
Angiotensin II-receptor antagonist in the treatment of hypertension
Volpe, M., Tocci, G., & Pagannone, E. (2005) · Current Hypertension Reports · doi:10.1007/s11906-005-0027-y · Cited by 4
Miyoshi, H., Takayama, Y., Kitashiro, S., Izuoka, T., Saito, D., Imuro, Y., Mimura, J., Yamamoto, S., Tokioka, M., & Iwasaka, T. (2002) · The Japanese Journal of Pharmacology · doi:10.1254/jjp.89.120 · Cited by 4
Role of Angiotensin II in Reflex Tachycardia During Hypotension Caused by a Calcium Channel Blocker
Sato, K., Chatani, F., & Sato, S. (1996) · Clinical and Experimental Hypertension · doi:10.3109/10641969609081770 · Cited by 3
Tissue angiotensin II and myocardial infarction
Sun, Y., & Weber, K. T. (1996) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-8988-9_29 · Cited by 3
Chiba, S., & Malik, K. U. (1981) · Life Sciences · doi:10.1016/0024-3205(81)90134-x · Cited by 3
Self-citationExpression of Human Angiotensinogen-Renin in Rat
Bartel, S., Hoch, B., Vetter, D., & Krause, E. (2002) · Hypertension · doi:10.1161/hy0202.103275 · Cited by 3
Cardiac Action of Angiotensin II
Endoh, M. (2001) · Elsevier eBooks · doi:10.1016/b978-012656975-9/50037-7 · Cited by 3
A view of the cardiac rhythm control: Intrinsic regulation
Ad, N., Kotel’nikov, S. A., Mazhara, Y. P., & Naumov, K. M. (2005) · Human Physiology · doi:10.1007/s10747-005-0034-z · Cited by 3
Komoriya, M., Imai, S., Aoyama, H., Yagi, H., Nagashima, M., Enomoto, M., Suzuki, K., Yamaji, S., Takase, H., Matsudaira, K., et al. (2008) · Journal of Arrhythmia · doi:10.1016/s1880-4276(08)80003-8 · Cited by 2
Hemodynamic Adaptive Mechanisms in Heart Failure
Hussey, A., Eastaugh, L., & Weintraub, R. G. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-802393-8.00005-3 · Cited by 2
Das Renin-Angiotensin-System: Physiologie und Pathophysiologie
GALLINAT, S., Edling, O., & Unger, T. (1999) · Steinkopff eBooks · doi:10.1007/978-3-642-93705-7_1 · Cited by 2
Molecular Biology of Tissue Renin
Peters, J., Lindpaintner, K., & Ganten, D. (1989) · Springer eBooks · doi:10.1007/978-3-642-83858-3_17 · Cited by 2
A Novel Molecule of the Angiotensin II Receptor Blocker Class: Focus on Olmesartan Medoxomil
Volpe, M., & Trimarco, B. (2005) · High Blood Pressure & Cardiovascular Prevention · doi:10.2165/00151642-200512020-00004 · Cited by 1
Calcium Signaling and Pharmacology of Cardiotonic Agents
Endoh, M. (1995) · Developments in cardiovascular medicine · doi:10.1007/978-1-4615-2021-4_14 · Cited by 1
Wang, Q., & Nygren, E. (2003) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.2003.01143.x · Cited by 1
Paul, M., & Schunkert, H. (1992) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-7321-5_48 · Cited by 1
The Renin-Angiotensin System and the Heart
Gavras, H. P., & Gavras, I. (1999) · Humana Press eBooks · doi:10.1007/978-1-59259-708-6_4 · Cited by 1
STUDIES ON HAEMORRHAGE AND EFFECTS OF SODIUM
Frithiof, R. (2007)
Fitzpatrick, M. A., Rademaker, M. T., & Espiner, E. A. (1994) · Springer eBooks · doi:10.1007/978-1-4615-2464-9_15
Matorra, L. F., Deutsch, A. C. R., Goyeneche, M. A., Garmendia, C. M., Rando, M., Celaya, C., Casanova, V., Cicale, E. M., & Basso, N. (2013) · Revista Argentina de Cardiología · doi:10.7775/rac.es.v81.i6.3325
Chiba, S., Furukawa, Y., Saegusa, K., & Yasuhiro, O. H. B. A. (1988) · Japanese Heart Journal · doi:10.1536/ihj.29.841
Self-citationPurification of an Angiotensin II Receptor
Elton, T. S., Oparil, S., & Blalock, J. E. (1990) · Humana Press eBooks · doi:10.1007/978-1-4612-0477-0_19
Sayin, H. (2017) · theses.fr (ABES) · doi:10.70675/a812af34zc99az466bz8694z9650a75596fb
Perivascular Peptides in the Coronary Circulation: Relation to Pathophysiology
Clarke, J. G. (1993) · Elsevier eBooks · doi:10.1016/b978-0-12-232350-8.50022-4
Costa, T. C. P. (2019) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.17.2019.tde-08052019-145620
Matorra, L. F., Deutsch, A. C. R., Goyeneche, M. A., Garmendia, C. M., Casanova, V., Rando, M., Celaya, C., Cicale, E. M., & Basso, N. (2013) · Revista Argentina de Cardiología · doi:10.7775/rac.v81.i6.3325
Das Renin-Angiotensin-System: Physiologie und Pathophysiologie
GALLINAT, S., Edling, O., & Unger, T. (1997) · Steinkopff eBooks · doi:10.1007/978-3-642-53757-8_1
Hemodynamic adaptive mechanisms in heart failure
Hussey, A., Eastaugh, L., & Weintraub, R. G. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-13279-7.00010-9
Deniau, B. (2020) · theses.fr (ABES) · doi:10.70675/58e60e7bz58d0z4839zbce3z1aaf9556bd1e
Wiese, S., Schmidt‐Schweda, S., Füchtbauer, E., Beyersdorf, F., & Holubarsch, C. (1998) · Progress in experimental cardiology · doi:10.1007/978-1-4615-5743-2_28
Urata, H., Hoffmann, S., Nishimura, H., Baltatu, O. C., Strobel, F., Krause, T., & Ganten, D. (1996) · Springer eBooks · doi:10.1007/978-3-642-79645-6_2
Metadata
- Authors
- Kobayashi, M., Furukawa, Y., & Chiba, S.
- Affiliations
- Shinshu University (JP)
- Corresponding author
- Chiba, Shigetoshi
- Venue
- European Journal of Pharmacology
- Publisher
- Elsevier BV
- Published
- 1978-07
- Volume
- 50
- Issue
- 1
- Pages
- 17-25
- ISSN
- 0014-2999 (ISSN-L)
- OpenAlex
- W1999422984
- Cited by
- 132
- References
- 13
- Citations by year
- 2025: 1 · 2021: 2 · 2020: 1 · 2019: 3 · 2017: 2 · 2013: 2 · 2012: 2
- FWCI
- 1.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- Locations
- European Journal of Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Health Sciences › Medicine › Surgery › Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Keywords
- angiotensin II, positive chronotropic effect, positive inotropic effect, sinoatrial node, atrial contractility, ventricular contractility, angiotensin II receptor, saralasin, beta-adrenergic blockade, propranolol, carteolol, isolated atria, isolated ventricle, dog heart
- MeSH terms
- Angiotensin II, Animals, Dogs, Heart Rate, Injections, Intra-Arterial, Injections, Intravenous, Jugular Veins, Myocardial Contraction, Norepinephrine, Propranolol, Saralasin, Stimulation, Chemical, In Vitro Techniques
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
