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(-)-Propranolol blocks the inhibition of serotonergic dorsal raphe cell firing by 5-HT1A selective agonists
Open accessAbstract
The ability of the beta-adrenoceptor antagonist propranolol to block the effects of serotonin (5-HT) and 5-HT1A-selective agonists on the spontaneous firing of serotonergic dorsal raphe neurons was assessed. During microiontophoretic application, (-)- but not (+)-propranolol rapidly and reversibly blocked the suppressant effects of the 5-HT1A-selective agonists ipsapirone (TVX Q 7821) and 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT). However, (-)-propranolol was a relatively weak antagonist of 5-HT itself, suggesting that the endogenous neurotransmitter may have actions on dorsal raphe neurons in addition to those mediated by 5-HT1A receptors.
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Cited by
Stockmeier, C. A., Shapiro, L. A., Dilley, G. E., Kolli, T. N., Friedman, L., & Rajkowska, G. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-18-07394.1998 · Cited by 429
Serotonin receptors involved in antidepressant effects
Artigas, F. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2012.09.006 · Cited by 311
Genetic variation in cortico-amygdala serotonin function and risk for stress-related disease
Holmes, A. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.03.006 · Cited by 264
Origin and functional role of the extracellular serotonin in the midbrain raphe nuclei
Adell, A., Celada, P., Abellán, M. T., & Artigas, F. (2002) · Brain Research Reviews · doi:10.1016/s0165-0173(02)00182-0 · Cited by 254
Psilocybin links binocular rivalry switch rate to attention and subjective arousal levels in humans
Carter, O. L., Hasler, F., Pettigrew, J. D., Wallis, G. M., Liu, G. B., & Vollenweider, F. X. (2007) · Psychopharmacology · doi:10.1007/s00213-007-0930-9 · Cited by 146
Metadata
- Authors
- Sprouse, J. S., & Aghajanian, G. K.
- Venue
- European Journal of Pharmacology
- Publisher
- Elsevier BV
- Published
- 1986-09
- Volume
- 128
- Issue
- 3
- Pages
- 295-298
- ISSN
- 0014-2999 (ISSN-L)
- OpenAlex
- W2054240764
- Cited by
- 306
- References
- 0
- FWCI
- 5.99
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: (-)-Propranolol blocks the inhibition of serotonergic dorsal raphe cell firing by 5-HT1A selective agonists. https://app.cochat.ai/papers/10.1016/0014-2999(86)90782-x
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- Sprouse, J. S., & Aghajanian, G. K. (1986). (-)-Propranolol blocks the inhibition of serotonergic dorsal raphe cell firing by 5-HT1A selective agonists. European Journal of Pharmacology. https://doi.org/10.1016/0014-2999(86)90782-x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
