Development of tolerance and supersensitivity to phencyclidine in rats after repeated administration of phencyclidine

Nabeshima, Toshitaka; Fukaya, Hiroaki; Yamaguchi, Kazumasa; Ishikawa, Kazuhiro; Furukawa, Hiroshi; Kameyama, Tsutomu

doi:10.1016/0014-2999(87)90753-9

Development of tolerance and supersensitivity to phencyclidine in rats after repeated administration of phencyclidine

In rats treated with phencyclidine (PCP) repeatedly (PCP 10 mg/kg per day for 14 days), the back-pedalling, head-weaving and turning induced by PCP were attenuated (tolerance), while PCP-induced sniffing, rearing and ambulation were potentiated (supersensitivity). The behavior induced by the dire…