Interactions of selective serotonin reuptake inhibitors with subtypes of σ receptors in rat brain
Abstract
The interactions of selective serotonin reuptake inhibitors and tricyclic antidepressants with subtypes of sigma receptors were investigated. The rank order of affinity (Ki values) from competition experiments of [3H](+)-pentazocine binding to sigma 1 sites was: fluvoxamine > sertraline > S(+)-fluoxetine > (+/-)-fluoxetine > citalopram > imipramine > paroxetine > desipramine > R(-)-fluoxetine > (+/-)-norfluoxetine. The Ki values of all drugs for sigma 2 sites were more than 1000 nM. Furthermore, all drugs were more potent at sigma 1 sites than at sigma 2 sites. These findings suggest that sigma receptors (sigma 1 site) may play, in some way, a role in the actions of selective serotonin reuptake inhibitors.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Activation of S1R by SSRIs enhances BDNF expression.
“In like manner, activation of S1R by SSRIs enhances BDNF expression (105, 106).”
From Psychedelics and Neuroplasticity: A Systematic Review Unraveling the Biological Underpinnings of Psychedelics. (2021) · cites this paper as [106]
No citation lists for this paper
No citation lists for this paper yet — checked again daily.
References 12 · Cited by 254
- Authors
- Narita, N., Hashimoto, K., Tomitaka, S.-I., & Minabe, Y.
- Affiliations
- National Center of Neurology and Psychiatry (JP)
- Corresponding author
- Hashimoto, Kenji
- ORCID
- Hashimoto, Kenji
- Venue
- European Journal of Pharmacology
- Publisher
- Elsevier BV
- Published
- 1996-06
- Volume
- 307
- Issue
- 1
- Pages
- 117-119
- ISSN
- 0014-2999 (ISSN-L)
- OpenAlex
- W1970897378
- Cited by
- 254
- References
- 12
- Citations by year
- 2026: 4 · 2025: 10 · 2024: 5 · 2023: 5 · 2022: 16 · 2021: 15 · 2020: 8 · 2019: 7 · 2018: 7 · 2017: 13 · 2016: 6 · 2015: 9 · 2014: 13 · 2013: 18 · 2012: 17
- FWCI
- 1.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pharmacological Receptor Mechanisms and Effects
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- selective serotonin reuptake inhibitors, sigma receptors, sigma-1 receptor, sigma-2 receptor, tricyclic antidepressants, fluoxetine, fluvoxamine, sertraline, citalopram, paroxetine, imipramine, desipramine, receptor binding affinity, drug interactions
- MeSH terms
- Animals, Antidepressive Agents, Tricyclic, Brain, Desipramine, Fluoxetine, Imipramine, Male, Stereoisomerism, Rats, Sprague-Dawley, Selective Serotonin Reuptake Inhibitors, Receptors, Opioid, delta, Antidepressive Agents, Second-Generation, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
