Familial hyperlipoproteinemia type III: Deficiency of a specific apolipoprotein (APO E‐III) in the very‐low‐density lipoproteins
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APOE2 homozygosity can lead to Hyperlipoproteinemia type III (HLP), characterized by mixed hypercholesterolemia and hypertriglyceridemia.
“The critical role of APOE in lipid metabolism is underscored by evidence showing that APOE2 homozygosity can lead to Hyperlipoproteinemia type III (HLP), characterized by mixed hypercholesterolemia and hypertriglyceridemia [35–39].”
APOE2hAβ rats are characterized as a model for type III HLP.
“This observation, coupled with evident mixed hypercholesterolemia and hypertriglyceridemia, supports the characterization of APOE2hAβ rats as a model for type III HLP”
Homozygosity for apoE2 is associated with recessive transmission of type III hlp.
“Homozygosity for the polymorphic form apoE2(Cys112, Cys158), the most common of these defective variants, is associated with recessive transmission of type III hlp (4).”
From Preferential association of apolipoprotein E Leiden with very low density lipoproteins of human plasma. (1993) · cites this paper as [4]
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References 19 · Cited by 337
- Authors
- Utermann, G., Jaeschke, M., & Menzel, J.
- Affiliations
- Philipps University of Marburg (DE)
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1975-08
- Volume
- 56
- Issue
- 2
- Pages
- 352-355
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2044755530
- Cited by
- 337
- References
- 19
- Citations by year
- 2025: 1 · 2024: 2 · 2022: 2 · 2021: 4 · 2020: 1 · 2019: 3 · 2018: 3 · 2017: 3 · 2016: 2 · 2015: 1 · 2014: 1 · 2012: 3
- FWCI
- 13.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- FEBS Letters (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Keywords
- apolipoprotein E, apolipoprotein E3, VLDL, lipoprotein metabolism
- MeSH terms
- Apoproteins, Electrophoresis, Polyacrylamide Gel, Fasting, Humans, Hyperlipidemias, Isoelectric Focusing, Lipoproteins, LDL, Lipoproteins, VLDL
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