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The biosynthesis of uroporphyrinogen III: Order of assembly of the four porphobilinogen molecules in the formation of the tetrapyrrole ring
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Hydroxymethylbilane can enter two pathways: URO3S closes the HMB macrocycle to uroporphyrinogen III; alternatively HMB undergoes spontaneous cyclization to uroporphyrinogen I.
“Hydroxymethylbilane can then enter two pathways. The first one uses uroporphyrinogen III synthase (URO3S) to close the HMB macrocycle leading to conversion of tetrapyrolle to uroporphyrinogen III. Alternatively, HMB can undergo spontaneous cyclization, which leads to the formation of uroporphyrinogen I [16].”
From Aminolevulinic Acid (ALA) as a Prodrug in Photodynamic Therapy of Cancer (2011) · cites this paper as [16]
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Prokaryotic Heme Biosynthesis: Multiple Pathways to a Common Essential Product
Dailey, H. A., Dailey, T. A., Gerdes, S., Jahn, D., Jahn, M., O'Brian, M. R., & Warren, M. J. (2017) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00048-16 · Cited by 340
Aminolevulinic Acid (ALA) as a Prodrug in Photodynamic Therapy of Cancer
Wachowska, M., Muchowicz, A., Firczuk, M., Gabrysiak, M., Winiarska, M., Wańczyk, M., Bojarczuk, K., & Golab, J. (2011) · Molecules · doi:10.3390/molecules16054140 · Cited by 265
Metadata
- Authors
- Jordan, P. M., & Seehra, J. S.
- Affiliations
- University of Southampton (GB)
- ORCID
- Seehra, J.S.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1979-08-15
- Volume
- 104
- Issue
- 2
- Pages
- 364-366
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2077103054
- Cited by
- 60
- References
- 0
- Citations by year
- 2024: 2 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 1 · 2017: 1 · 2013: 2 · 2012: 1
- FWCI
- 1.78
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- FEBS Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Porphyrin Metabolism and Disorders
- Physical Sciences › Materials Science › Materials Chemistry › Porphyrin and Phthalocyanine Chemistry
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Photodynamic Therapy Research Studies
- Keywords
- uroporphyrinogen III, porphobilinogen, heme biosynthesis, delta-aminolevulinic acid dehydratase
- MeSH terms
- Porphobilinogen Synthase, Carbon Radioisotopes, Coproporphyrinogen Oxidase, Hydroxymethylbilane Synthase, Porphyrinogens, Rhodobacter sphaeroides, Uroporphyrinogen Decarboxylase, Uroporphyrinogen III Synthetase, Uroporphyrinogens
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