The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
The role of citric acid in intermediate metabolism in animal tissues
Abstract
In the present paper experiments are reported which throw new light on the problem of the intermediate stages of oxidation of carbohydrate; in conjunction with the work of Szent‐Györgyi 20), Stare and Baumann 19) and Martius and Knoop 13,14) the new experiments allow us to outline the principal steps of the oxidation of sugar in animal tissues.
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In the citing paper
“At the nexus of both catabolic and anabolic metabolism lies the tricarboxylic acid (TCA) cycle, a broadly conserved metabolic pathway consisting of a cyclic series of chemical reactions that harness high-energy electrons from fuel sources (1, 2, 3).”
From Regulation and function of the mammalian tricarboxylic acid cycle (2023) · cites this paper as [2]
In the citing paper
“By adding malonate, an inhibitor of succinate oxidation, they found that succinate accumulated when OAA was added to muscle, implying that this series of reactions was cyclical in nature (2, 32).”
From Regulation and function of the mammalian tricarboxylic acid cycle (2023) · cites this paper as [2]
In the citing paper
“Moreover, they found that citrate did not disappear during this process, indicating that it was being continuously reformed (2, 32).”
From Regulation and function of the mammalian tricarboxylic acid cycle (2023) · cites this paper as [2]
In the citing paper
“These crucial experiments teed up the findings of Hans Krebs and his colleague William Johnson (2) in Enzymologia in 1937, in which they discovered that citrate was readily oxidized by minced pigeon breast muscle and that citrate addition increased oxygen uptake beyond the amount necessary for the complete oxidation of the added citrate, indicating that citrate itself was stimulating consumption”
From Regulation and function of the mammalian tricarboxylic acid cycle (2023) · cites this paper as [2]
Citations
Cites
Krebs, H. A. (1935) · Biochemical Journal · doi:10.1042/bj0291620 · Cited by 777
Self-citationMetabolism of ketonic acids in animal tissues
Krebs, H. A., & Johnson, W. A. (1937) · Biochemical Journal · doi:10.1042/bj0310645 · Cited by 357
Self-citationUntersuchungen über den Stoffwechsel der Aminosäuren im Tierkörper. Mit 2 Figuren im Text.
Krebs, H. A. (1933) · Hoppe-Seyler´s Zeitschrift für physiologische Chemie · doi:10.1515/bchm2.1933.217.5-6.191 · Cited by 296
Self-citationThe malic dehydrogenase of animal tissues
Green, D. E. (1936) · Biochemical Journal · doi:10.1042/bj0302095 · Cited by 192
A METHOD TO DETERMINE SMALL AMOUNTS OF CITRIC ACID IN BIOLOGICAL MATERIAL
Pucher, G. W., Sherman, C. C., & Vickery, H. B. (1936) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)74909-0 · Cited by 191
Östberg, O. (1931) · Skandinavisches Archiv Für Physiologie · doi:10.1111/j.1748-1716.1931.tb01441.x · Cited by 112
Über den Abbau der Citronensäure.
Martins, C. (1937) · Hoppe-Seyler´s Zeitschrift für physiologische Chemie · doi:10.1515/bchm2.1937.247.3.104 · Cited by 92
Weil‐Malherbe, H. (1937) · Biochemical Journal · doi:10.1042/bj0310299 · Cited by 80
Weil‐Malherbe, H., & Krebs, H. A. (1935) · Biochemical Journal · doi:10.1042/bj0292077 · Cited by 66
Self-citationÜber die Bedeutung der Pumarsäure für die tierische Gewebsatmung. - III. Mitteilung.
Annau, E., Banga, I., Blazso, A., Bruckner, T., Laki, K., Straub, F. B., & Szent‐Györgyi, A. (1936) · Hoppe-Seyler´s Zeitschrift für physiologische Chemie · doi:10.1515/bchm2.1936.244.3-4.105 · Cited by 57
Research works printed but not linked: 9
- Bernhauer, 1934, Ergebn. Enzymf., 3, 185
- Blaise, 1908, C.R., 147, 198
- Krebs, 1933, Zs. phys. Chem., 218, 151
- Kutscher, 1903, Zs. phys. Chem., 39, 474
- Ljunggren, 1925, Katalytisk Kolsyreavspjälkning ur Kotokarbonsyror, Lund
- Malachowski, 1928, Ber. Chem. Ges., 61, 2524
- Pollak, 1907, Hofmeisters Beitr., 10, 232
- Szent-Györgyi c.s., 1925, Bioch. Zs., 162, 399
- Szent-Györgyi c.s., 1935, Z. phys. Chem., 236, 1
Cited by
Sorted by citations
Regulation and function of the mammalian tricarboxylic acid cycle
Arnold, P. K., & Finley, L. W. S. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102838 · Cited by 535
“Their work also showed that large quantities of citrate could be synthesized anaerobically by muscle in the presence of OAA and that OAA, when added to muscle, condensed with two carbon atoms from an unknown precursor to form citrate (2).”
BackgroundResultInfluentialReprogramming mitochondrial metabolism in macrophages as an anti‐inflammatory signal
Mills, E. L., & O'Neill, L. A. J. (2015) · European Journal of Immunology · doi:10.1002/eji.201445427 · Cited by 454
Krebs cycle Reborn in macrophage immunometabolism
Ryan, D. G., & O'Neill, L. A. J. (2020) · Annual Review of Immunology · doi:10.1146/annurev-immunol-081619-104850 · Cited by 444
Energy metabolism in health and diseases
Liu, H., Wang, S., Wang, J., Guo, X., Song, Y., Fu, K., Gao, Z., Liu, D., He, W., & Yang, L. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02141-x · Cited by 484
Quantum mechanical tunnelling in biological systems
Devault, D. (1980) · Quarterly Reviews of Biophysics · doi:10.1017/s003358350000175x · Cited by 406
Metadata
- Authors
- Krebs, H. A., & Johnson, W. A.
- Affiliations
- University of Sheffield (GB)
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1980-08-25
- Volume
- 117
- Issue
- S1
- Pages
- K1-10
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2019649025
- Cited by
- 249
- References
- 22
- Citations by year
- 2026: 9 · 2025: 14 · 2024: 12 · 2023: 12 · 2022: 18 · 2021: 18 · 2020: 16 · 2019: 9 · 2018: 17 · 2017: 14 · 2016: 9 · 2015: 7 · 2014: 6 · 2013: 6 · 2012: 6
- FWCI
- 0.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- FEBS Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Biochemical Acid Research Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial metabolism and enzyme function
- Keywords
- citric acid, intermediary metabolism, carbohydrate oxidation, sugar oxidation, animal tissues, TCA cycle
- MeSH terms
- Biochemistry, Citric Acid Cycle, England, History, 20th Century
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