Resistance to apamin of the Ca2+‐activated K+ permeability in pancreatic B‐cells
Abstract
The bee venom neurotoxin apamin failed to affect 86Rb outflow and insulin release from rat pancreatic islets stimulated by D-glucose or the Ca2+-ionophore A23187. Apamin, in contrast to quinine or A23187, also failed to affect bioelectrical activity in mouse islet cells. These findings suggest that, like in erythrocytes, and at variance with the situation found in smooth muscle, liver or neuroblastoma cells, the Ca2+-activated K+ permeability in the pancreatic B-cell is resistant to apamin.
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An early report found that apamin is without effect on either glucose-induced electrical activity or the amplitude of the Kslow current.
“An early report that apamin is without effect on either glucose-induced electrical activity (374) or the amplitude of the Kslow current (12, 223) was therefore surprising (although see (669)).”
From Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men (2018) · cites this paper as [374]
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Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men
Rorsman, P., & Ashcroft, F. M. (2018) · Physiological Reviews · doi:10.1152/physrev.00008.2017 · Cited by 793 · see citing works
- Authors
- Lebrun, P., Atwater, I., Claret, M., Malaisse, W. J., & Herchuelz, A.
- Affiliations
- University of East Anglia (GB)
- Université Libre de Bruxelles (BE)
- ORCID
- Malaisse, W.J.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1983-09-05
- Volume
- 161
- Issue
- 1
- Pages
- 41-44
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2043973154
- Cited by
- 34
- References
- 0
- Citations by year
- 2018: 1 · 2017: 1 · 2012: 1
- FWCI
- 1.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- FEBS Letters (publishedVersion)
- PubMed (publishedVersion)
- Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
- Keywords
- apamin, calcium-activated potassium channels, pancreatic beta cells, insulin secretion, potassium permeability, quinine, A23187, glucose-stimulated insulin secretion
- MeSH terms
- Calcimycin, Insulin Secretion, Animals, Apamin, Bee Venoms, Calcium, Glucose, Insulin, Islets of Langerhans, Kinetics, Permeability, Potassium, Rubidium, Rats
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