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Common evolutionary origin of the fibrin‐binding structures of fibronectin and tissue‐type plasminogen activator
Abstract
Comparison of the primary structures of high‐M r urokinase and tissue‐type plasminogen activator reveals a high degree of structural homology between the two proteins, except that tissue activator contains a 43 residue long amino‐terminal region, which has no counterpart in urokinase. We show that this segment is homologous with the finger‐domains responsible for the fibrin‐affinity of fibronectin. Limited proteolysis of the amino‐terminal region of plasminogen activator was found to lead to a loss of the fibrin‐affinity of the enzyme. It is suggested that the finger‐domains of fibronectin and tissue‐types plasminogen activator have similar functions and that the finger‐domains of the two proteins evolved from a common ancestral fibrin‐binding domain.
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Citations
Cited by
Cell-Associated Plasminogen Activation: Regulation and Physiological Functions
Saksela, O., & Rifkin, D. B. (1988) · Annual Review of Cell Biology · doi:10.1146/annurev.cb.04.110188.000521 · Cited by 818
Molecular Biology of Fibronectin
Hynes, R. (1985) · Annual Review of Cell Biology · doi:10.1146/annurev.cb.01.110185.000435 · Cited by 601
Natural Selection and the Origin of jingwei , a Chimeric Processed Functional Gene in Drosophila
Long, M., & Langley, C. H. (1993) · Science · doi:10.1126/science.7682012 · Cited by 416
Ny, T., Elgh, F., & Lund, B. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.17.5355 · Cited by 299
Modular Assembly of Genes and the Evolution of New Functions
Patthy, L. (2003) · Genetica · doi:10.1023/a:1024182432483 · Cited by 166
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Metadata
- Authors
- Bányai, L., Váradi, A., & Patthy, L.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1983-10-31
- Volume
- 163
- Issue
- 1
- Pages
- 37-41
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2040551353
- Cited by
- 237
- References
- 0
- FWCI
- 12.51
- Type
- journal article
- Language
- en
- Open access
- closed
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- Bányai, L., Váradi, A., & Patthy, L. (1983). Common evolutionary origin of the fibrin‐binding structures of fibronectin and tissue‐type plasminogen activator. FEBS Letters. https://doi.org/10.1016/0014-5793(83)81157-0
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