The DOI matches its Crossref record.
Carbachol and oxytocin stimulate the generation of inositol phosphates in the guinea pig myometrium
Abstract
In the guinea pig myometrium prelabelled with myo‐[2‐3 H]inositol, carbachol and oxytocin enhanced a concentration‐dependent and rapid release of IP 3 which preceded that of IP 2 and IP 1. The specific receptor‐mediated phospholipase C activation degrading PIP 2 to IP 3 did not require the presence of extracellular Ca 2+. The ionophore A23187 as well as K+ depolarization failed to increase inositol phosphate accumulation. It is proposed that IP 3 could have a role in the contraction of uterine smooth muscle elicited by the activation of muscarinic as well as of oxytocin receptors.
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Cited by
Receptor-effector coupling by G proteins
Birnbaumer, L., Abramowitz, J., & Brown, A. M. (1990) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/0304-4157(90)90007-y · Cited by 1,118
Insel, T. R. (1992) · Psychoneuroendocrinology · doi:10.1016/0306-4530(92)90073-g · Cited by 487
Gene Regulation in the Magnocellular Hypothalamo-Neurohypophysial System
Burbach, J. P. H., Luckman, S. M., Murphy, D., & Gainer, H. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.3.1197 · Cited by 340
Structural bases of vasopressin/oxytocin receptor function
Barberis, C., Mouillac, B., & Durroux, T. (1998) · Journal of Endocrinology · doi:10.1677/joe.0.1560223 · Cited by 311
Are animal models relevant to key aspects of human parturition?
Mitchell, B. F., & Taggart, M. J. (2009) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00153.2009 · Cited by 265
Metadata
- Authors
- Marc, S., Leiber, D., & Harbon, S.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1986-05-26
- Volume
- 201
- Issue
- 1
- Pages
- 9-14
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2006050008
- Cited by
- 161
- References
- 0
- FWCI
- 2.49
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Carbachol and oxytocin stimulate the generation of inositol phosphates in the guinea pig myometrium. https://app.cochat.ai/papers/10.1016/0014-5793(86)80561-0
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- Marc, S., Leiber, D., & Harbon, S. (1986). Carbachol and oxytocin stimulate the generation of inositol phosphates in the guinea pig myometrium. FEBS Letters. https://doi.org/10.1016/0014-5793(86)80561-0
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
