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Amino‐aromatic interactions in proteins
Open accessAbstract
Geometric analysis of 33 refined high‐resolution protein crystal structures (2 Å or higher) demonstrates that side‐chain amino groups interact with aromatic side chains. Positively charged or δ(+) amino groups of lysine, arginine, asparagine, glutamine and histidine are preferentially located within 6 Å of the ring centroids of phenylalanine, tyrosine and trytophan, where they make van der Waals' contact with the δ(−) π‐electrons and avoid the δ(+) ring edge. This geometric pattern is different from the distribution expected due to random close packing of side chains in a protein. It is opposite to oxygen‐ and sulfur‐aromatic interactions, similar to aromatic‐aromatic interactions, and almost certainly electrostatic in origin.
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Cited by
Radhakrishnan, I., Pérez-Alvarado, G. C., Parker, D., Dyson, H. J., Montminy, M. R., & Wright, P. E. (1997) · Cell · doi:10.1016/s0092-8674(00)80463-8 · Cited by 728
The Bright Future of Unconventional σ/π‐Hole Interactions
Bauzá, A., Mooibroek, T. J., & Frontera, A. (2015) · ChemPhysChem · doi:10.1002/cphc.201500314 · Cited by 710
The NPXY internalization signal of the LDL receptor adopts a reverse-turn conformation
Bansal, A., & Gierasch, L. M. (1991) · Cell · doi:10.1016/0092-8674(91)90295-a · Cited by 192
Tyr115 is the key residue for determining agonist selectivity in the V1a vasopressin receptor
Chini, B., Mouillac, B., Ala, Y., Balestre, M. N., Trumpp‐Kallmeyer, S., Hoflack, J., Elands, J., Hibert, M., Manning, M., & Jard, S. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb07211.x · Cited by 179
Fasan, R., Dias, R. L. A., Moehle, K., Zerbe, O., Obrecht, D., Mittl, P. R. E., Grütter, M. G., & Robinson, J. A. (2006) · ChemBioChem · doi:10.1002/cbic.200500452 · Cited by 129
Metadata
- Authors
- Burley, S. K., & Petsko, G. A.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1986-07-28
- Volume
- 203
- Issue
- 2
- Pages
- 139-143
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2080796053
- Cited by
- 759
- References
- 0
- FWCI
- 8.99
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Burley, S. K., & Petsko, G. A. (1986). Amino‐aromatic interactions in proteins. FEBS Letters. https://doi.org/10.1016/0014-5793(86)80730-x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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