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Brain 14‐3‐3 protein is an activator protein that activates tryptophan 5‐monooxygenase and tyrosine 3‐monooxygenase in the presence of Ca2+,calmodulin‐dependent protein kinase II
Abstract
We have found that the 14‐3‐3 protein, an acidic neuronal protein, is substantially identical to the ‘activator’ protein [(1981) J. Biol. Chem. 256, 5404–5409] that activates tryptophan 5‐monooxygenase and tyrosine 3‐monooxygenase in the presence of Ca 2+,calmodulin dependent protein kinase II. This finding is based on the remarkable similarity of both these proteins in physicochemical, biochemical and immunochemical properties, as well as on detection for the 14‐3‐3 protein of an activator activity towards tryptophan 5‐monooxygenase. The result suggests that the 14‐3‐3 protein plays a role in the regulation of serotonin and noradrenaline biosynthesis in brain.
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Citations
Cited by
Tyrosine hydroxylase and regulation of dopamine synthesis
Daubner, S. C., Le, T., & Wang, S. (2011) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2010.12.017 · Cited by 1,092
14-3-3 proteins in the nervous system
Berg, D., Holzmann, C., & Riess, O. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1197 · Cited by 616
14-3-3 proteins: a highly conserved, widespread family of eukaryotic proteins
Aitken, A., Collinge, D. B., van Heusden, B. P. H., Isobe, T., Roseboom, P. H., Rosenfeld, G., & Soll, J. (1992) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(92)90339-b · Cited by 494
Self-citationComplex molecular regulation of tyrosine hydroxylase
Tekin, I., Roskoski, R., Carkaci-Salli, N., & Vrana, K. E. (2014) · Journal of Neural Transmission · doi:10.1007/s00702-014-1238-7 · Cited by 128
Regulation of tyrosine hydroxylase by stress-activated protein kinases
Toska, K., Kleppe, R., Armstrong, C. G., Morrice, N. A., Cohen, P., & Haavik, J. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.01172.x · Cited by 95
Metadata
- Authors
- Ichimura, T., Isobe, T., Okuyama, T., Yamauchi, T., & Fujisawa, H.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1987-07-13
- Volume
- 219
- Issue
- 1
- Pages
- 79-82
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2006067437
- Cited by
- 285
- References
- 0
- FWCI
- 0.92
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Brain 14‐3‐3 protein is an activator protein that activates tryptophan 5‐monooxygenase and tyrosine 3‐monooxygenase in the presence of Ca2+,calmodulin‐dependent protein kinase II. https://app.cochat.ai/papers/10.1016/0014-5793(87)81194-8
- The paper
- Ichimura, T., Isobe, T., Okuyama, T., Yamauchi, T., & Fujisawa, H. (1987). Brain 14‐3‐3 protein is an activator protein that activates tryptophan 5‐monooxygenase and tyrosine 3‐monooxygenase in the presence of Ca2+,calmodulin‐dependent protein kinase II. FEBS Letters. https://doi.org/10.1016/0014-5793(87)81194-8
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