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Proline residues in the maturation and degradation of peptide hormones and neuropeptides
Open accessAbstract
The proteases involved in the maturation of regulatory peptides like those of broader specificity normally fail to cleave peptide bonds linked to the cyclic amino acid proline. This generates several mature peptides with N‐terminal X‐Prosequences. However, in certain non‐mammalian tissues repetitive pre‐sequences of this type are removed by specialized dipeptidyl (amino)peptidases during maturation. In mammals, proline‐specific proteases are not involved in the biosynthesis of regulatory peptides, but due to their unique specificity they could play an important role in the degradation of them. Evidence exists that dipeptidyl (amino)peptidase IV at the cell surface of endothelial cells sequesters circulating peptide hormones which are then susceptible to broader aminopeptidase attack. The cleavage of several neuropeptides by prolyl endopeptidase has been demonstrated in vitro, but its role in the brain is questionable since the precise localization of the protease is not clarified.
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Cited by
MENTLEIN, R., GALLWITZ, B., & SCHMIDT, W. E. (1993) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1993.tb17986.x · Cited by 1,161
Self-citationDipeptidyl peptidase 4 inhibitors in the treatment of type 2 diabetes mellitus
Deacon, C. F. (2020) · Nature Reviews Endocrinology · doi:10.1038/s41574-020-0399-8 · Cited by 398
Grandt, D., Schimiczek, M., Beglinger, C., Layer, P., Goebell, H., Eysselein, V. E., & Reeve, J. R. (1994) · Regulatory Peptides · doi:10.1016/0167-0115(94)90204-6 · Cited by 364
Proteolytic processing of neuropeptide Y and peptide YY by dipeptidyl peptidase IV
Mentlein, R., Dahms, P., Grandt, D., & Krüger, R. (1993) · Regulatory Peptides · doi:10.1016/0167-0115(93)90435-b · Cited by 349
Self-citationThe prolyl oligopeptidase family
Polgár, L. (2002) · Cellular and Molecular Life Sciences CMLS · doi:10.1007/s00018-002-8427-5 · Cited by 311
Metadata
- Authors
- Mentlein, R.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1988-07-18
- Volume
- 234
- Issue
- 2
- Pages
- 251-256
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2026178423
- Cited by
- 203
- References
- 0
- FWCI
- 3.07
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Mentlein, R. (1988). Proline residues in the maturation and degradation of peptide hormones and neuropeptides. FEBS Letters. https://doi.org/10.1016/0014-5793(88)80092-9
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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