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Selective activation of the γ‐subspecies of protein kinase C from bovine cerebellum by arachidonic acid and its lipoxygenase metabolites
Abstract
The γ‐subspecies of protein kinase C (PKC) apparently is expressed only in central nervous tissues, and at a high level in the cerebellum and hippocampus. γ‐PKC from bovine cerebellum, but not the α‐or βI/βII‐subspecies, is activated by micromolar concentrations of arachidonic acid (AA), in the absence of both phospholipid and diacylglycerol. A significant component of this activation is also calcium independent. Other unsaturated fatty acids are much less active in this respect. Among the AA metabolites tested, lipoxin A (5(S),6(R),15(S)‐11‐cis‐isomer) was a potent, selective activator of the γ‐subspecies, and also, to a lesser extent, 12(S)‐hydroxy‐5,8,10,14‐eicosatetraenoic acid could support activation. These results raise the possibility that AA and some of its lipoxygenase metabolites may function as messenger molecules in neurones to activate the γ‐subspecies of PKC.
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Cited by
Arachidonic acid and free fatty acids as second messengers and the role of protein kinase C
Khan, W. A., Blobe, G. C., & Hannun, Y. A. (1995) · Cellular Signalling · doi:10.1016/0898-6568(94)00089-t · Cited by 225
Metadata
- Authors
- Shearman, M. S., Naor, Z., Sekiguchi, K., Kishimoto, A., & Nishizuka, Y.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1989-01-30
- Volume
- 243
- Issue
- 2
- Pages
- 177-182
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2052028692
- Cited by
- 184
- References
- 0
- FWCI
- 9.79
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Selective activation of the γ‐subspecies of protein kinase C from bovine cerebellum by arachidonic acid and its lipoxygenase metabolites. https://app.cochat.ai/papers/10.1016/0014-5793(89)80125-5
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- Shearman, M. S., Naor, Z., Sekiguchi, K., Kishimoto, A., & Nishizuka, Y. (1989). Selective activation of the γ‐subspecies of protein kinase C from bovine cerebellum by arachidonic acid and its lipoxygenase metabolites. FEBS Letters. https://doi.org/10.1016/0014-5793(89)80125-5
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