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Cited by 239

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

Formation and release of nitric oxide from human neutrophils and HL‐60 cells induced by a chemotactic peptide, platelet activating factor and leukotriene B4

Open access
Schmidt, Harald H.H.W., Seifert, Roland, Böhme, Eycke·1989·FEBS Letters

Abstract

Vascular endothelial cells and neutrophils synthesize and release potent vasodilatatory factors, i.e. endothelium‐derived relaxing factors (EDRF) and neutrophil‐derived relaxing factors (NDRF). One EDRF has been identified as nitric oxide (NO) derived from arginine. We studied the synthesis and release of NO from human neutrophils stimulated with the chemotactic peptide N‐formyl‐L‐methionyl‐L‐leucyl‐L‐phenylalanine, platelet activating factor or leukotriene B 4. The formation and release of NO was enhanced several‐fold in the presence of superoxide dismutase, probably by inhibiting superoxide‐induced breakdown of NO. The formation and release of NO but not the formation of superoxide anions was decreased in neutrophils pretreated with L‐canavanine, an inhibitor of arginine‐utilizing enzymes. Our data suggest that at least one NDRF is identical with NO or another labile NO containing compound derived from arginine.

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Metadata

Authors
Schmidt, H. H. H. W., Seifert, R., & Böhme, E.
Venue
FEBS Letters
Publisher
Wiley
Published
1989-02-27
Volume
244
Issue
2
Pages
357-360
ISSN
  • 0014-5793 (ISSN-L)
  • 1873-3468
OpenAlex
W2084654400
Cited by
239
References
3
FWCI
16.31
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Formation and release of nitric oxide from human neutrophils and HL‐60 cells induced by a chemotactic peptide, platelet activating factor and leukotriene B4. https://app.cochat.ai/papers/10.1016/0014-5793(89)80562-9
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Schmidt, H. H. H. W., Seifert, R., & Böhme, E. (1989). Formation and release of nitric oxide from human neutrophils and HL‐60 cells induced by a chemotactic peptide, platelet activating factor and leukotriene B4. FEBS Letters. https://doi.org/10.1016/0014-5793(89)80562-9

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