Glucose‐induced oscillations of intracellular Ca2+ concentration resembling bursting electrical activity in single mouse islets of Langerhans
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Intracellular Ca 2+ levels were monitored in single, acutely isolated mouse islets of Langerhans by dual emission Indo‐1 fluorometry. High‐frequency (3.1 min−1) [Ca 2+]i, oscillations with a brief rising time (1–2 s) and 10 s half‐width (‘fast’ oscillations) were detected in 11 mM glucose. Raising the glucose concentration to 16.7 mM increased the duration of these oscillations, which were otherwise absent in 5.5 mM glucose. [Ca 2+]i waves of lower frequency (0.5 min−1) and longer rising time (‘slow’ oscillations) were also recorded. The data indicate that “fast” oscillations are directly related to β‐cell bursting electrical activity, and suggest the existence of extensive networks of electrically coupled cells in the islet.
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Electrical activity is accompanied by changes in cytoplasmic free Ca2+, which drive pulsatile insulin secretion.
“Electrical activity is accompanied by changes in cytoplasmic free Ca2+ ([Ca2+]i) (701) (Figure 5C), which in turn drive pulsatile insulin secretion (210).”
From Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men (2018) · cites this paper as [701]
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References 16 · Cited by 206
Research works printed but not linked: 2
- Perez-Armendariz, E. and Atwater, I. (1986) in: Biophysics of the PancreaticBCell (Atwater, I., Rojas, E. and Soria, B. eds) Adv. Exp. Med. Biol., ~01.211, pp.41-51, Plenum, New York.
- Rosario, L.M., Atwater, I. and Scott, A.M. (1986) in: Biophysics of the Pancreatic @Cell (Atwater, I., Rojas, E. and Soria, B. eds) Adv. Exp. Med. Biol., ~01.211, pp.413-425, Plenum, New York.
- Authors
- Valdeolmillos, M., Santos, R. M., Contreras, D., Soria, B., & Rosario, L. M.
- Affiliations
- University of Alicante (ES)
- Corresponding author
- Valdeolmillos, Miguel
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1989-12-18
- Volume
- 259
- Issue
- 1
- Pages
- 19-23
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2036441475
- Cited by
- 206
- References
- 16
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 2 · 2023: 4 · 2022: 3 · 2021: 4 · 2020: 5 · 2019: 1 · 2018: 1 · 2017: 3 · 2016: 1 · 2015: 5 · 2014: 7 · 2013: 8
- FWCI
- 14.46
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- FEBS Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Connexins and lens biology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Keywords
- calcium oscillations, pancreatic islets, electrical coupling, glucose, beta-cell electrical activity, calcium waves, mouse islets
- MeSH terms
- Animals, Calcium, Cytoplasm, Dose-Response Relationship, Drug, Electrophysiology, Extracellular Space, Glucose, Islets of Langerhans, Periodicity, Mice, In Vitro Techniques
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