Secretion of islet amyloid polypeptide in response to glucose
Open accessAbstract
The content of isolet amyloid polypeptide (IAPP) in isolated rat pancreatic islets was determined by a radioimmunoassay. Reverse‐phase high‐performance liquid chromatography analysis revealed that a main peak of IAPP immunoreactivity in the extracts from the islets corresponded to a synthetic rat IAPP. Secretion of IAPP from the cells is regulated by the extracellular glucose concentration. Thus, IAPP may be a novel regulator for glucose homeostasis and changes in the secretion perhaps relate to insular amyloid deposits and impaired glucose tolerance in type 2 diabetes mellitus.
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IAPP is co-secreted with insulin from β-cells in response to glucose stimulation at an approximate >1:20 stoichiometry.
“IAPP is co-secreted with insulin from β-cells in response to glucose stimulation at an approximate >1:20 stoichiometry (330).”
From Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men (2018) · cites this paper as [330]
The discussion (section labeled “Dilution”; page unavailable) says that IAPP was co-secreted with insulin from isolated rat pancreatic islets and that secretion was regulated by glucose. It does not state an IAPP-to-insulin stoichiometry of approximately >1:20; the Figure 3 caption describes the measurements but gives no ratio. (LLM, conf=0.84)
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Cooper, G. J., Willis, A. C., Clark, A., Turner, R. C., Sim, R. B., & Reid, K. B. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.23.8628 · Cited by 1,299 · see citing works
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- Westermark, P., Wernstedt, C., Wilander, E., Hayden, D.W., O'Brien, T.D. and Johnson, K.H. (1987) Proc. Natl. Acad. Sci. USA 84, 3881-3885.
- Cooper, G.J.S., Wills, A.C., Claj, A., Turner, B.C., Sim, R.B. and Reid, K.B.M. (1987) Proc. Natl. Acad. Sci. USA 84, 8628-8632.
- Leffert, J.D., Newgard, C.B., Okamoto, H., Milburn, J.L. and Luskey, K.L. (1989) Proc. Natl. Acad. Sci. USA 87,3127-3130.
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Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men
Rorsman, P., & Ashcroft, F. M. (2018) · Physiological Reviews · doi:10.1152/physrev.00008.2017 · Cited by 793 · see citing works
Evidence of Cosecretion of Islet Amyloid Polypeptide and Insulin by β-Cells
Kahn, S. E., D'Alessio, D. A., Schwartz, M. W., Fujimoto, W. Y., Ensinck, J. W., Taborsky, G. J., & Porte, D. (1990) · Diabetes · doi:10.2337/diab.39.5.634 · Cited by 454 · see citing works
Amylin: Pharmacology, Physiology, and Clinical Potential
Hay, D. L., Chen, S., Lutz, T. A., Parkes, D. G., & Roth, J. D. (2015) · Pharmacological Reviews · doi:10.1124/pr.115.010629 · Cited by 400 · see citing works
Zakariassen, H. L., John, L. M., & Lutz, T. A. (2020) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.13427 · Cited by 37 · see citing works
- Authors
- Kanatsuka, A., Makino, H., Ohsawa, H., Tokuyama, Y., Yamaguchi, T., Yoshida, S., & Adachi, M.
- Affiliations
- Chiba University (JP)
- JIMRO (Japan) (JP)
- Corresponding author
- Kanatsuka, A.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1989-12-18
- Volume
- 259
- Issue
- 1
- Pages
- 199-201
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W1967006902
- Cited by
- 107
- References
- 1
- Citations by year
- 2026: 3 · 2022: 2 · 2021: 1 · 2020: 1 · 2018: 1 · 2017: 4 · 2016: 1 · 2015: 2 · 2014: 1 · 2013: 1 · 2012: 1
- FWCI
- 20.30
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- FEBS Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Keywords
- amylin, glucose regulation, pancreatic islets, glucose homeostasis, type 2 diabetes, impaired glucose tolerance
- MeSH terms
- Amyloid, Animals, Diabetes Mellitus, Type 2, Glucose, Islets of Langerhans, Male, Radioimmunoassay, Secretory Rate, Rats, Islet Amyloid Polypeptide, In Vitro Techniques
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