Liposome‐associated retinoic acid: Increased in vitro antiproliferative effects on neoplastic cells
Open accessAbstract
The activity of liposome‐associated retinoic acid was analyzed on in vitro cultured tumor cell lines and compared to the antiproliferative effects of free retinoic acid. It was found that liposome‐associated retinoic acid is about 300 times more active than free retinoic acid in inhibiting in vitro cell growth of leukemic and melanoma cell lines. An increased activity of retinoic acid (10–20 times) was also obtained after premixing of this compound with empty liposomes, demonstrating that the retinoic acid efficiently interacts with liposomes which may facilitate solubility and cell uptake of retinoids.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In vitro tests showed that ATRA-containing liposomes or ATRA-containing polymeric nanoparticles were 100-1000 times more active than soluble ATRA in cultured tumor cells or neural stem cells.
“In vitro tests showed that ATRA-containing liposomes69 or ATRA-containing polymeric nanoparticles25,44 were 100–1000 times more active than soluble ATRA in cultured tumor cells25,69 or neural stem cells (NSC)44.”
From Advances and challenges in retinoid delivery systems in regenerative and therapeutic medicine (2020) · cites this paper as [69]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
The citation lists haven’t been fetched yet
References 15 · Cited by 30
Research works printed but not linked: 7
- Sporn, M.B., Roberts, A.B. and Goodman, P.S. (1984) The Retinoids, Academic Press, Orlando.
- Blomhoff, R., Helgerud, P., Rasmussen, M., Berg, T. and Not-urn, K.R. (1982) Proc. Natl. Acad. Sci. USA 79,7326-7330.
- Nastruzzi, C., Walde, P., Manegatti, E. and Gambari, R. Bio- chim. Biophys. Acta, in press.
- Miiller, M., Marti, T. and Kriz, S. (1980) in: Electron Micro- scopy, vol. 2 (Brederoo, P. and DePrester, W. eds) pp. 770-772, Seventh European Congress on Electronmicroscopy Founda- tion, Leiden.
- Friend, C., Scher, W., Holland, J.G. and Sato, T. (1971) Proc. Natl. Acad. Sci. USA 68, 378-382.
- Szoka, F. and Papahadjopoulos, D. (1978) Proc. Natl. Acad. Sci. USA 75, 4194-4198.
- Senior, J.H., Gregoriadis, G., Muller, D.P.R., Pathak, Y.V. and McIntyre, N. (1989) B&hem. Sot. Trans. 17, 121-122.
- Authors
- Nastruzzi, C., Walde, P., Menegatti, E., & Gambari, R.
- Affiliations
- ETH Zurich (CH)
- University of Ferrara (IT)
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1990-01
- Volume
- 259
- Issue
- 2
- Pages
- 293-296
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W1579469509
- Cited by
- 30
- References
- 15
- Citations by year
- 2026: 1 · 2021: 2 · 2020: 1 · 2018: 2 · 2014: 1 · 2013: 2
- FWCI
- 0.42
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- FEBS Letters (publishedVersion)
- PubMed (publishedVersion)
- Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion)
- Funders
- Regione del Veneto
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinoids in leukemia and cellular processes
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Keywords
- retinoic acid, liposomes, antiproliferative activity, leukemia cell lines, melanoma cell lines, cell growth inhibition, cellular uptake, drug delivery
- MeSH terms
- Animals, Cell Division, Drug Carriers, Leukemia, Erythroblastic, Acute, Freeze Fracturing, Humans, Liposomes, Melanoma, Microscopy, Electron, Phosphatidylcholines, Tretinoin, Tumor Cells, Cultured, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
