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Hydrogen peroxide production during experimental protein glycation
Open accessAbstract
The accumulation of hydrogen peroxide (H 2 O 2) during incubations of protein with glucose (experimental glycation) has previously been too low for direct measurement although it is suggested to be the precursor of protein‐damaging hydroxylating agents. We have thus developed a simple H 2 O 2‐measuring technique which relies upon the rapid peroxide‐mediated oxidation of Fe 2+ to Fe 3+ (catalysed by sorbitol) under acidic conditions followed by reaction of the latter cation with the dye, xylenol orange. We have used the method to demonstrate that incubation mixtures of protein and glucose generates nanomolar levels of hydrogen peroxide in the presence of protein under physiological conditions of pH and temperature.
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Citations
Cited by
Diabetes, oxidative stress, and antioxidants: A review
Maritim, A. C., Sanders, R. A., & Watkins, J. B. (2003) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.10058 · Cited by 3,124
Chandel, N. S., McClintock, D. S., Feliciano, C. E., Wood, T. M., Melendez, J. A., Rodriguez, A. M., & Schumacker, P. T. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001914200 · Cited by 2,000
Jiang, Z.-Y., Hunt, J. V., & Wolff, S. P. (1992) · Analytical Biochemistry · doi:10.1016/0003-2697(92)90122-n · Cited by 1,620
Self-citationWolff, S. P. (1994) · Methods in Enzymology · doi:10.1016/s0076-6879(94)33021-2 · Cited by 1,244
Self-citationBierhaus, A. (1998) · Cardiovascular Research · doi:10.1016/s0008-6363(97)00233-2 · Cited by 555
Metadata
- Authors
- Jiang, Z.-Y., Woollard, A. C. S., & Wolff, S. P.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1990-07-30
- Volume
- 268
- Issue
- 1
- Pages
- 69-71
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2009077462
- Cited by
- 515
- References
- 0
- FWCI
- 2.56
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Hydrogen peroxide production during experimental protein glycation. https://app.cochat.ai/papers/10.1016/0014-5793(90)80974-n
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- Jiang, Z.-Y., Woollard, A. C. S., & Wolff, S. P. (1990). Hydrogen peroxide production during experimental protein glycation. FEBS Letters. https://doi.org/10.1016/0014-5793(90)80974-n
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
