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Paraoxonase prevents accumulation of lipoperoxides in low‐density lipoprotein
Abstract
Oxidative modification of low‐density lipoprotein (LDL) enhances its uptake by macrophages in tissue culture and in vivo may underly the formation of arterial fatty streaks, the progenitors of atheroma. We investigated the possible protection which high‐density lipoprotein (HDL) affords against LDL oxidation. The formation of lipoperoxides and thiobarbituric acid reactive substances when LDL was incubated with copper ions was significantly decreased by HDL. The enzyme, paraoxonase (E.C. 3.1.8.1), purified from human HDL, had a similar effect and thus may be the component of HDL responsible for decreasing the accumulation of lipid peroxidation products.
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Citations
Cited by
Bhattacharyya, T. (2008) · JAMA · doi:10.1001/jama.299.11.1265 · Cited by 533
Ng, C. J., Wadleigh, D. J., Gangopadhyay, A., Hama, S., Grijalva, V. R., Navab, M., Fogelman, A. M., & Reddy, S. T. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m105660200 · Cited by 466
Mackness, B., Davies, G. K., Turkie, W., Lee, E., Roberts, D. H., Hill, E., Roberts, C., Durrington, P. N., & Mackness, M. I. (2001) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/hq0901.094247 · Cited by 435
Self-citationHigh density lipoproteins and coronary heart disease
Barter, P. J., & Rye, K.-A. (1996) · Atherosclerosis · doi:10.1016/0021-9150(95)05675-0 · Cited by 377
Myeloperoxidase, paraoxonase-1, and HDL form a functional ternary complex
Huang, Y., Wu, Z., Riwanto, M., Gao, S., Levison, B. S., Gu, X., Fu, X., Wagner, M. A., Besler, C., Gerstenecker, G., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci67478 · Cited by 269
Metadata
- Authors
- Mackness, M. I., Arrol, S., & Durrington, P. N.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1991-07-29
- Volume
- 286
- Issue
- 1-2
- Pages
- 152-154
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2061663562
- Cited by
- 977
- References
- 0
- FWCI
- 3.23
- Type
- journal article
- Language
- en
- Open access
- closed
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- Mackness, M. I., Arrol, S., & Durrington, P. N. (1991). Paraoxonase prevents accumulation of lipoperoxides in low‐density lipoprotein. FEBS Letters. https://doi.org/10.1016/0014-5793(91)80962-3
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
