The DOI matches its Crossref record.
Molecular cloning and nucleotide sequence determination of the regulator region of mecA gene in methicillin‐resistant Staphylococcus aureus (MRSA)
Abstract
Molecular cloning and nucleotide sequence analysis were performed for the identification or the regulator genes of methicillin resistance in the genome of a MRSA strain N315. Two open reading frames (orfs) were identified in the 5′‐flanking region of the mecA gene. Predicted amino acid sequences of these orfs showed extensive homology to the co‐inducer and the repressor protein of the penicillinase (PCase) production in Staphylococcus aureus as well as in Bacillus licheniformis. These orfs are considered to encode putative co‐inducer and repressor proteins specific for the regulation of methicillin resistance in MRSA.
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Citations
Cited by
Methicillin-Resistant Staphylococcus aureus: Molecular Characterization, Evolution, and Epidemiology
Lakhundi, S., & Zhang, K. (2018) · Clinical Microbiology Reviews · doi:10.1128/cmr.00020-18 · Cited by 1,637
Ito, T., Katayama, Y., Asada, K., Mori, N., Tsutsumimoto, K., Tiensasitorn, C., & Hiramatsu, K. (2001) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.45.5.1323-1336.2001 · Cited by 963
Self-citationEpidemiology of β-Lactamase-Producing Pathogens
Bush, K., & Bradford, P. A. (2020) · Clinical Microbiology Reviews · doi:10.1128/cmr.00047-19 · Cited by 938
Ma, X. X., Ito, T., Tiensasitorn, C., Jamklang, M., Chongtrakool, P., Boyle-Vavra, S., Daum, R. S., & Hiramatsu, K. (2002) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.46.4.1147-1152.2002 · Cited by 587
Self-citationNew Directions in Antibacterial Research
Chu, D. T. W., Plattner, J. J., & Katz, L. (1996) · Journal of Medicinal Chemistry · doi:10.1021/jm960294s · Cited by 298
Metadata
- Authors
- Hiramatsu, K., Asada, K., Suzuki, E., Okonogi, K., & Yokota, T.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1992-02-24
- Volume
- 298
- Issue
- 2-3
- Pages
- 133-136
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2005695870
- Cited by
- 182
- References
- 0
- FWCI
- 5.50
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Molecular cloning and nucleotide sequence determination of the regulator region of mecA gene in methicillin‐resistant Staphylococcus aureus (MRSA). https://app.cochat.ai/papers/10.1016/0014-5793(92)80039-j
- The paper
- Hiramatsu, K., Asada, K., Suzuki, E., Okonogi, K., & Yokota, T. (1992). Molecular cloning and nucleotide sequence determination of the regulator region of mecA gene in methicillin‐resistant Staphylococcus aureus (MRSA). FEBS Letters. https://doi.org/10.1016/0014-5793(92)80039-j
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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