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SC‐0051, a 2‐benzoyl‐cyclohexane‐1,3‐dione bleaching herbicide, is a potent inhibitor of the enzyme p‐hydroxyphenylpyruvate dioxygenase
Open accessAbstract
Growth inhibition of Lemna gibba plantlets by the bleaching herbicide, SC‐0051 (2‐(2‐chloro‐4‐methanesulfonylbenzoyl)‐1,3‐cyclohexanedione)) was alleviated by the addition of homogentisic acid to the growth medium. Homogentisic acid is a key intermediate in the biosynthesis of tyrosine‐derived plant quinones as well as in tyrosine metabolism. The herbicide prevented the incorporation of radioactivity from [14 C]tyrosine into lipophilic plant metabolites and, in rat liver extracts, the herbicide inhibited the conversion of tyrosine to homogentisic acid. The enzyme p‐hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27) from both Zea mays seedlings and liver tissues, was found to be subject to strong inhibition by SC‐0051. Inhibition of plant quinone biosynthesis is a new mode of herbicidal action. One of the consequences of quinone depletion in plants in vivo is apparently an indirect inhibition of phytoene desaturation. The enzyme phytoene desaturase itself, however, is not afflicted by the herbicide.
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Cited by
Norris, S. R., Barrette, T. R., & DellaPenna, D. (1995) · The Plant Cell · doi:10.1105/tpc.7.12.2139 · Cited by 432
4-Hydroxyphenylpyruvate dioxygenase
Moran, G. R. (2005) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2004.08.015 · Cited by 306
Lock, E. A., Gaskin, P., Ellis, M., Provan, W. M., & Smith, L. L. (2006) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2006.01.015 · Cited by 35
Metadata
- Authors
- Schulz, A., Ort, O., Beyer, P., & Kleinig, H.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1993-03
- Volume
- 318
- Issue
- 2
- Pages
- 162-166
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2012797544
- Cited by
- 192
- References
- 0
- FWCI
- 6.29
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: SC‐0051, a 2‐benzoyl‐cyclohexane‐1,3‐dione bleaching herbicide, is a potent inhibitor of the enzyme p‐hydroxyphenylpyruvate dioxygenase. https://app.cochat.ai/papers/10.1016/0014-5793(93)80013-k
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- Schulz, A., Ort, O., Beyer, P., & Kleinig, H. (1993). SC‐0051, a 2‐benzoyl‐cyclohexane‐1,3‐dione bleaching herbicide, is a potent inhibitor of the enzyme p‐hydroxyphenylpyruvate dioxygenase. FEBS Letters. https://doi.org/10.1016/0014-5793(93)80013-k
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