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Bilirubin and ascorbate antioxidant activity in neonatal plasma
Open accessAbstract
Extremely low birth weight premature infants have been known for many years to have limited antioxidant protective capacity, especially with reference to those antioxidant components which do not cross the placenta until the third trimester of gestation. In this study the total antioxidant activity and the concentrations of individual antioxidants in plasma from premature neonates (27 ± 2 weeks gestation) compared to term babies (38–41 weeks gestation) have been examined. The results show elevated levels of ascorbate at birth in the plasma of premature neonates compared with those of term babies, but the total plasma antioxidant status of the premature babies is significantly lower than that of term babies. At 5 days post‐partum the ascorbate levels are within the normal adult range and plasma bilirubin levels are considerably enhanced in both groups, while the total plasma antioxidant status of the premature neonates has increased. Analysis of the relationship between the total plasma antioxidant activity and the bilirubin concentration show a direct, highly significant correlation for the term group, r 2 = 0.774, consistent with significance of bilirubin as a plasma antioxidant.
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Cites
Ascorbate is an outstanding antioxidant in human blood plasma
Frei, B., England, L., & Ames, B. N. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.16.6377 · Cited by 1,870
Cited by
Antioxidants in health and disease
Young, I. S., & Woodside, J. V. (2001) · Journal of Clinical Pathology · doi:10.1136/jcp.54.3.176 · Cited by 1,949
A novel automated method to measure total antioxidant response against potent free radical reactions
Erel, O. (2004) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2003.10.014 · Cited by 1,765
Heme oxygenase: colors of defense against cellular stress
Otterbein, L. E., & Choi, A. M. K. (2000) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.2000.279.6.l1029 · Cited by 870
Free heme toxicity and its detoxification systems in human
Kumar, S., & Bandyopadhyay, U. (2005) · Toxicology Letters · doi:10.1016/j.toxlet.2005.03.004 · Cited by 852
Doré, S., Takahashi, M., Ferris, C. D., Hester, L. D., Guastella, D., & Snyder, S. H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.5.2445 · Cited by 699
Metadata
- Authors
- Gopinathan, V., Miller, N. J., Milner, A. D., & Rice-Evans, C. A.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1994-08
- Volume
- 349
- Issue
- 2
- Pages
- 197-200
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2095045934
- Cited by
- 208
- References
- 1
- FWCI
- 5.27
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Gopinathan, V., Miller, N. J., Milner, A. D., & Rice-Evans, C. A. (1994). Bilirubin and ascorbate antioxidant activity in neonatal plasma. FEBS Letters. https://doi.org/10.1016/0014-5793(94)00666-0
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.