Selective inhibition of the mitochondrial permeability transition pore at the oxidation‐reduction sensitive dithiol by monobromobimane
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In this paper we introduce monobromobimane, a thiol reagent, as a selective blocker of the recently identified dithiol whose oxidation‐reduction status modifies voltage sensing by the mitochondrial permeability transition pore, a cyclosporin A‐sensitive channel. Monobromobimane does not inhibit the phosphate carrier, nor does it interfere with Ca 2+ transport, energy coupling or ATP production and transport. We show that monobromobimane selectively prevents the shift in pore gating potential caused by some dithiol oxidants or crosslinkers but not by increasing [Ca 2+], allowing a clear distinction of the pore agonists which act at this site.
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ANT has three thiols implicated in its function that are located in three distinct hydrophilic loops.
“ANT has three thiols that are implicated in its function that are located in three distinct hydrophilic loops (102, 167, 171, 286).”
From Redox regulation of mitochondrial function (2012) · cites this paper as [102]
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References 20 · Cited by 88
Research works printed but not linked: 2
- Kosower, N.S., Kosower, N.M, Newton, G.L. and Ranney, H.M. (1979) Proc. Natl. Acad. Sci. USA 76, 3382 3386.
- Costantini, R, Petronilli, V., Colonna, R. and Bernardi, P. (1995) Toxicology, in press.
- Authors
- Costantini, P., Chernyak, B. V., Petronilli, V., & Bernardi, P.
- Affiliations
- University of Padua (IT)
- Corresponding author
- Bernardi, Paolo
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1995-04-03
- Volume
- 362
- Issue
- 2
- Pages
- 239-242
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W1998491986
- Cited by
- 88
- References
- 20
- Citations by year
- 2025: 1 · 2023: 1 · 2021: 1 · 2020: 2 · 2019: 1 · 2016: 2 · 2015: 3 · 2014: 1 · 2013: 1 · 2012: 1
- FWCI
- 2.85
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- FEBS Letters (publishedVersion)
- PubMed (publishedVersion)
- Padua Research Archive (University of Padova) (submittedVersion)
- Funders
- Università degli Studi di Padova
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › ATP Synthase and ATPases Research
- Keywords
- monobromobimane, mitochondrial permeability transition pore, sulfhydryl reagents, voltage sensing, mitochondrial calcium transport, phosphate transporters
- MeSH terms
- Adenosine Triphosphate, Animals, Bridged Bicyclo Compounds, Calcium, Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone, Intracellular Membranes, Ion Channels, Mitochondria, Liver, Oxidation-Reduction, Oxygen Consumption, Permeability, Phosphates, Toluene, Calcium Channels, Ion Channel Gating, Cyclosporine, Rats
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