The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Induction of vascular endothelial growth factor expression in synovial fibroblasts by prostaglandin E and interleukin‐1: a potential mechanism for inflammatory angiogenesis
Open accessAbstract
Inflammatory mediators such as prostaglandin E 2 (PGE 2) and interleukin‐1 (IL‐1) induce angiogenesis by yet undefined mechanisms. We demonstrate that PGE 2 and IL‐1 induces the expression of vascular endothelial growth factor (VEGF), a selective angiogenic factor by rheumatoid synovial fibroblast cells. Transcripts for the EP 1 and EP 2, subtypes of PGE receptors are expressed in synovial fibroblasts. Activators of protein kinase A pathway stimulated the expression of VEGF whereas down‐regulation of protein kinase C did not influence the PGE effect, suggesting that signalling from the EP 2 receptor via the protein kinase A pathway is important. The induction of VEGF expression by PGE 2 and interleukin‐1α a may be an important mechanism in inflammatory angiogenesis.
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Cited by
Molecular and biological properties of vascular endothelial growth factor
Ferrara, N. (1999) · Journal of Molecular Medicine · doi:10.1007/s001099900019 · Cited by 1,158
Immunobiology of endometriosis
Lebovic, D. I., Mueller, M. D., & Taylor, R. N. (2001) · Fertility and Sterility · doi:10.1016/s0015-0282(00)01630-7 · Cited by 857
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Role of vascular endothelial growth factor in the regulation of angiogenesis
Ferrara, N. (1999) · Kidney International · doi:10.1046/j.1523-1755.1999.00610.x · Cited by 731
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Bonnet, C. S. (2005) · Rheumatology · doi:10.1093/rheumatology/keh344 · Cited by 709
Metadata
- Authors
- Ben-Av, P., Crofford, L. J., Wilder, R. L., & Hla, T.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1995-09-18
- Volume
- 372
- Issue
- 1
- Pages
- 83-87
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2032894856
- Cited by
- 566
- References
- 38
- FWCI
- 12.38
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Induction of vascular endothelial growth factor expression in synovial fibroblasts by prostaglandin E and interleukin‐1: a potential mechanism for inflammatory angiogenesis. https://app.cochat.ai/papers/10.1016/0014-5793(95)00956-a
- The paper
- Ben-Av, P., Crofford, L. J., Wilder, R. L., & Hla, T. (1995). Induction of vascular endothelial growth factor expression in synovial fibroblasts by prostaglandin E and interleukin‐1: a potential mechanism for inflammatory angiogenesis. FEBS Letters. https://doi.org/10.1016/0014-5793(95)00956-a
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
