A new hepatocyte stimulating factor: cardiotrophin‐1 (CT‐1)
Open accessAbstract
Recently, a novel cytokine, cardiotrophin‐1 (CT‐1), was cloned and found to induce cardiac myocyte hypertrophy in vitro. Amino acid sequence similarity showed CT‐1 to be a member of the IL‐6/LIF/CNTF/OSM/IL‐11 cytokine family. Since all known members of the IL‐6 cytokine family induce an hepatic acute phase protein (APP) gene expression, we investigated the ability of CT‐1 to induce a liver acute phase response. Upon stimulation of rat hepatoma cells, CT‐1 and LIF induced the strongest rat fibrinogen mRNA expression, OSM and IL‐6 induced a less pronounced response. When human hepatoma cells and primary rat hepatocytes were stimulated with CT‐1, the expression of human haptoglobin and rat α 2‐macroglobulin mRNA was induced. The induction of the acute phase response was dose‐ and time‐dependent. In this study we demonstrate that CT‐1, a novel cytokine belonging to the IL‐6 cytokine family, is a hepatocyte stimulating factor.
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OSM, LIF, and CT-1 have been implicated in liver functions such as development, hepatocyte differentiation, or inflammation, but have not yet been examined in liver regeneration.
“These cytokines have been implicated in liver functions such as development, hepatocyte differentiation, or inflammation (31)(32)(33), but have yet to be examined in liver regeneration.”
From Expression of suppressors of cytokine signaling during liver regeneration (2001) · cites this paper as [32]
The Introduction and Results and discussion link CT-1, LIF, and OSM to hepatocyte acute-phase responses associated with inflammation. The paper does not address liver development or hepatocyte differentiation, and although it does not study liver regeneration, it does not establish that these cytokines had yet to be examined in that setting. (LLM, conf=0.84)
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References 27 · Cited by 39
Research works printed but not linked: 4
- Kushner, I. and Mackiewicz, A. (1993) in: (Maickiewicz, A., Kush- ner, I. and Baumann, H. eds.) Acute Phase Proteins. Molecular Biology, Biochemistry and Clinical Applications, CRC Press, Boca Raton.
- Gauldie, J., Richards, C., Harnish, D., Landsdorp, E and Baumann, H. (1987) Proc. Natl. Aca& Sci. USA 84, 7251 7255.
- Pennica, D., King, K.L., Shaw, K.J., Luis, E., Rullamas, J., Luoh, S.M., Darbonne, W.C., Knutzon, D.S., Yen, R., Chien, K.R., Baker, J.B. and Wood, W.I. (1995) Proc. Natl. Acad. Sci. USA 92, 1142-46.
- Roeb, E., Graeve, L., Hoffmann, R., Decker, K., Edwards, D.R. and Heinrich, EC. (1993) Hepatology 18, 11437-42. 18733468, 1995, 2-3, Downloaded from https://febs.onlinelibrary.wiley.com/doi/10.1016/0014-5793(95)00972-C, Wiley Online Library on [29/05/2023]. See the Terms and Conditions (https://onlinelibrary.wiley.com/terms-and-conditions) on Wiley Online Library for rules of use; OA articles are governed by the applicable Creative Commons License
- Authors
- Peters, M., Roeb, E., Pennica, D., zum Büschenfelde, K.-H. M., & Rose-John, S.
- Affiliations
- Johannes Gutenberg University Mainz (DE)
- RWTH Aachen University (DE)
- Genentech (US)
- ORCID
- Roeb, Elke
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1995-09-25
- Volume
- 372
- Issue
- 2-3
- Pages
- 177-180
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2140843625
- Cited by
- 39
- References
- 27
- Citations by year
- 2024: 1 · 2022: 1 · 2021: 1 · 2019: 1 · 2018: 1 · 2015: 1 · 2013: 1
- FWCI
- 1.83
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- FEBS Letters (publishedVersion)
- PubMed (publishedVersion)
- RWTH Publications (RWTH Aachen) (submittedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Life Sciences › Immunology and Microbiology › Immunology › Biomarkers in Disease Mechanisms
- Keywords
- cardiotrophin-1, hepatocyte-stimulating factor, acute phase response, fibrinogen, haptoglobin, alpha2-macroglobulin, hepatocyte gene expression
- MeSH terms
- Acute-Phase Proteins, Animals, Carcinoma, Hepatocellular, Humans, Tumor Cells, Cultured, Gene Expression, Cytokines, Rats
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