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Cell surface binding and activation of gelatinase A induced by expression of membrane-type-1-matrix metalloproteinase (MT1-MMP).
Abstract
Gelatinase A is secreted as a proenzyme (progelatinase A) which is activated and bound on the surface of tumor and normal cells. We have reported that the expression of a membrane‐type‐1‐matrix metalloproteinase (MT1‐MMP) induces activation of progelatinase A. Here we demonstrate that the expression of MT1‐MMP in COS‐1 cells induces cell‐surface binding of progelatinase A which is consequently processed to an intermediate form. Processing from the intermediate to the fully active form is dependent on the gelatinase A concentration. These results suggest that the cell‐surface binding concentrates the gelatinase A intermediate form locally to allow autoproteolytic processing to the fully active form.
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Activation of MMP-2 by MT1-MMP allows MMP-2 access to membrane substrates such as APP, which would not otherwise be accessible for this soluble MMP.
“A plausible scenario would be that activation of MMP-2 by MT1-MMP (Sato et al., 1996) allows MMP-2 access to membrane substrates (i.e., APP), which would not otherwise be accessible for this soluble MMP.”
From Emerging Alternative Proteinases in APP Metabolism and Alzheimer’s Disease Pathogenesis: A Focus on MT1-MMP and MT5-MMP (2019) · cites this paper as Sato et al., 1996
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Cui, N., Hu, M., & Khalil, R. A. (2017) · Progress in Molecular Biology and Translational Science · doi:10.1016/bs.pmbts.2017.02.005 · Cited by 1,359
Ohuchi, E., Imai, K., Fujii, Y., Sato, H., Seiki, M., & Okada, Y. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.4.2446 · Cited by 938
Self-citationZuo, J., Ferguson, T. A., Hernandez, Y. J., Stetler-Stevenson, W. G., & Muir, D. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-14-05203.1998 · Cited by 270
Self-citationNorgauer, J., Hildenbrand, T., Idzko, M., Panther, E., Bandemir, E., Hartmann, M., Vanscheidt, W., & Herouy, Y. (2002) · British Journal of Dermatology · doi:10.1046/j.1365-2133.2002.05025.x · Cited by 101
Matrix Metalloproteinases as New Targets in Alzheimer’s Disease: Opportunities and Challenges
Zipfel, P., Rochais, C., Baranger, K., Rivera, S., & Dallemagne, P. (2020) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.0c00352 · Cited by 94
García-González, L., Pilat, D., Baranger, K., & Rivera, S. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00244 · Cited by 88
Metadata
- Authors
- Sato, H., Takino, T., Kinoshita, T., Imai, K., Okada, Y., Stetler Stevenson, W. G., & Seiki, M.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1996-05-06
- Volume
- 385
- Issue
- 3
- Pages
- 238-240
- ISSN
- 0014-5793
- 1873-3468
- Cited by
- 150
- References
- 0
- Language
- en
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