The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Ectopic expression of CHOP (GADD153) induces apoptosis in M1 myeloblastic leukemia cells
Open accessAbstract
CHOP (GADD153) is a member of the C/EBP family and a stress‐induced protein. To investigate the role of CHOP in cellular growth, we expressed CHOP conditionally in M1 myeloblastic leukemia cells that do not express p53 protein. More than 60% of M1 cells died through apoptosis 72 h after CHOP induction. Site‐directed mutagenesis revealed that this process requires leucine zipper domain but neither intact basic region nor trans‐activation domain. CHOP‐mediated apoptosis accompanied downregulation of bcl‐2 mRNA and overexpression of Bcl‐2 delayed the process. Our results indicate that CHOP can induce apoptosis in a p53‐independent manner.
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Cites
Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death
Oltval, Z. N., Milliman, C. L., & Korsmeyer, S. J. (1993) · Cell · doi:10.1016/0092-8674(93)90509-o · Cited by 6,003
Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells.
Cao, Z., Umek, R. M., & McKnight, S. L. (1991) · Genes & Development · doi:10.1101/gad.5.9.1538 · Cited by 1,663
Kinoshita, S., Akira, S., & Kishimoto, T. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.4.1473 · Cited by 327
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Cited by
Mediators of endoplasmic reticulum stress-induced apoptosis
Szegezdi, E., Logue, S. E., Gorman, A. M., & Samali, A. (2006) · The EMBO Reports · doi:10.1038/sj.embor.7400779 · Cited by 2,345
Islet Amyloid Polypeptide, Islet Amyloid, and Diabetes Mellitus
Westermark, P., Andersson, A., & Westermark, G. T. (2011) · Physiological Reviews · doi:10.1152/physrev.00042.2009 · Cited by 1,044
Targeted disruption of the chop gene delays endoplasmic reticulum stress-mediated diabetes
Oyadomari, S., Koizumi, A., Takeda, K., Gotoh, T., Akira, S., Araki, E., & Mori, M. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0214550 · Cited by 752
Self-citationTakekawa, M., & Saito, H. (1998) · Cell · doi:10.1016/s0092-8674(00)81619-0 · Cited by 746
Shuda, M., Kondoh, N., Imazeki, N., Tanaka, K., Okada, T., Mori, K., Hada, A., Arai, M., Wakatsuki, T., Matsubara, O., et al. (2003) · Journal of Hepatology · doi:10.1016/s0168-8278(03)00029-1 · Cited by 520
Metadata
- Authors
- Matsumoto, M., Minami, M., Takeda, K., Sakao, Y., & Akira, S.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1996-10-21
- Volume
- 395
- Issue
- 2-3
- Pages
- 143-147
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2103483160
- Cited by
- 321
- References
- 3
- FWCI
- 0.99
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Matsumoto, M., Minami, M., Takeda, K., Sakao, Y., & Akira, S. (1996). Ectopic expression of CHOP (GADD153) induces apoptosis in M1 myeloblastic leukemia cells. FEBS Letters. https://doi.org/10.1016/0014-5793(96)01016-2
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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