Brainstem tumor presenting as an upper gut motility disorder
Abstract
This case study of an adult with a medullary glioma documents the potential for brainstem lesions to present solely with symptoms of abnormal gastrointestinal motor function. The case illustrates the potential of manometric and scintigraphic techniques in confirming the presence of organic disease in patients with unexplained vomiting.
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Brainstem pathology may present with isolated vomiting or severe nausea due to involvement of the vomiting center in the floor of the fourth ventricle.
“Clinically, brainstem pathology may present with isolated vomiting or severe nausea due to involvement of the vomiting center in the floor of the fourth ventricle (Wood et al., 1985).”
From Autonomic nervous system and gastrointestinal manifestations with an emphasis on gastric dysfunction (2026) · cites this paper as Wood et al., 1985
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Gastrointestinal motility disorders in neurologic disease
Camilleri, M. (2021) · Journal of Clinical Investigation · doi:10.1172/jci143771 · Cited by 211 · see citing works
Self-citationAutonomic nervous system and gastrointestinal manifestations with an emphasis on gastric dysfunction
Shouman, K., Camilleri, M., & Singer, W. (2026) · Autonomic Neuroscience · doi:10.1016/j.autneu.2026.103474
Self-citation
- Authors
- Wood, J. R., Camilleri, M., Low, P. A., & Malagelada, J.-R.
- Affiliations
- Mayo Clinic (US)
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 1985-12
- Volume
- 89
- Issue
- 6
- Pages
- 1411-1414
- ISSN
- 0016-5085 (ISSN-L)
- OpenAlex
- W1887859606
- Cited by
- 51
- References
- 0
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 1 · 2022: 2 · 2021: 2 · 2018: 1 · 2016: 1 · 2015: 1 · 2014: 1 · 2012: 1
- FWCI
- 3.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01am026428-06)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Genetics › Glioma Diagnosis and Treatment
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal Tumor Research and Treatment
- Keywords
- brainstem tumors, vomiting, organic gastrointestinal disease, manometry, scintigraphy, atypical presentation
- MeSH terms
- Anorexia, Astrocytoma, Brain Neoplasms, Diagnosis, Differential, Gastrointestinal Motility, Humans, Male, Medulla Oblongata, Middle Aged, Nausea, Psychophysiologic Disorders
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