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Diminished survival in asymptomatic primary biliary cirrhosis
Open accessAbstract
Data from 73 asymptomatic patients with primary biliary cirrhosis were analyzed to determine clinical course and long-term survival. Of these, 44 entered a D-penicillamine treatment trial; 29 qualified but chose not to participate. Median follow-up was 7.6 yr (range, 2.8-12.2 yr). Liver biopsy at the initial visit showed advanced disease (fibrosis, cirrhosis) in 61% of the patients. During prospective clinical follow-up, which was available for 37 of the 44 study patients, one or more symptoms of liver disease developed in 33 (89%); esophageal varices were found in 15 (41%), and histologic progression to cirrhosis was found in 20 (67%) of the 30 precirrhotic patients. Significant (p less than 0.01) biochemical progression was reflected by a decrease in mean serum albumin concentrations and an increase in mean serum bilirubin levels in 32 patients followed for 4-6 yr. Survival data were available for all 73 patients; 17 died (11 secondary to liver failure), and 1 underwent liver transplantation. These patients had a 4-fold increase in mortality rate (p less than 0.001) compared with the U.S. population matched for age, race, and sex.
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“More recent studies with longer follow-up indicate that, although asymptomatic disease tends to progress at a much slower rate than symptomatic disease, survival of both symptomatic and asymptomatic patients with PBC is significantly less than that of the general population.125 126”
From The British Society of Gastroenterology/UK-PBC primary biliary cholangitis treatment and management guidelines (2018) · cites this paper as [125]
Citations
Cites
Nonparametric Estimation from Incomplete Observations
Kaplan, E. L., & Meier, P. (1992) · Springer series in statistics · doi:10.1007/978-1-4612-4380-9_25 · Cited by 45,239
Nonparametric Estimation from Incomplete Observations
Kaplan, E. L., & Meier, P. (1958) · Journal of the American Statistical Association · doi:10.1080/01621459.1958.10501452 · Cited by 39,158
Nonparametrics: Statistical Methods Based on Ranks
Mergenthaler, M. J., & Lehmann, E. L. (1979) · Technometrics · doi:10.2307/1268531 · Cited by 3,353
Nonparametrics: Statistical Methods Based on Ranks.
Beaver, R. J., & Lehmann, E. L. (1976) · Biometrics · doi:10.2307/2529529 · Cited by 2,067
A Class of Rank Test Procedures for Censored Survival Data
Harrington, D. P., & Fleming, T. R. (1982) · Biometrika · doi:10.1093/biomet/69.3.553 · Cited by 1,194
Staging of chronic nonsuppurative destructive cholangitis (syndrome of primary biliary cirrhosis)
Ludwig, J., Dickson, E. R., & McDonald, G. S. A. (1978) · Virchows Archiv A Pathological Anatomy and Histology · doi:10.1007/bf00432479 · Cited by 753
Self-citationCelaya, F. B. (1989) · PubMed · Cited by 508
The presentation and diagnosis of 100 patients with primary biliary cirrhosis
Sherlock, S., & Scheuer, P. J. (1973) · New England Journal of Medicine · doi:10.1056/nejm197309272891306 · Cited by 504
Roll, J., Boyer, J. L., Barry, D., & Klatskin, G. (1983) · New England Journal of Medicine · doi:10.1056/nejm198301063080101 · Cited by 417
Serum bilirubin: a prognostic factor in primary biliary cirrhosis
Shapiro, J. M., Smith, H., & Schaffner, F. (1979) · Gut · doi:10.1136/gut.20.2.137 · Cited by 319
Cited by
Sorted by citations
Items 101–140 of 140
Bhatia, A. S., & Mihas, A. A. (2006) · Postgraduate Medicine · doi:10.3810/pgm.2006.06.1645 · Cited by 3
Primary Biliary Cirrhosis and Sclerosing Cholangitis
Parés, A., & Rodés, J. (1992) · Springer eBooks · doi:10.1007/978-3-642-76802-6_22 · Cited by 6
Sherlock, F. S., & BSc, J. D. (2001) · Wiley eBooks · doi:10.1002/9780470986820.ch14 · Cited by 3
Heathcote, J. E., Cauch-Dudek, K., Walker, V., Bailey, R. J., Blendis, L. M., Ghent, C. N., Michieletti, P., Minuk, G. Y., Pappas, C. S., Scully, L. J., et al. (1994) · Hepatology · doi:10.1002/hep.1840190512 · Cited by 2
Zen, Y., Hübscher, S. G., & Nakanuma, Y. (2023) · Elsevier eBooks · doi:10.1016/b978-0-7020-8228-3.00009-0 · Cited by 2
Chronic cholestatic liver diseases
Blum, H. E. (2002) · Journal of Gastroenterology and Hepatology · doi:10.1046/j.1440-1746.17.s3.34.x · Cited by 2
King, P. D. (1991) · Postgraduate Medicine · doi:10.1080/00325481.1991.11700866 · Cited by 2
An unusual cause of subacute intestinal obstruction: Figure 1
Cheung, F. K. Y., Siu, W. T., Chiu, P. W. Y., & Ng, E. K. W. (2006) · Gut · doi:10.1136/gut.2005.076554 · Cited by 2
New directions in primary biliary cirrhosis.
Bateson, M. C. (1990) · BMJ · doi:10.1136/bmj.301.6764.1290 · Cited by 2
Immunosuppressive Treatment of Chronic Liver Disease
Jones, E. A., & Bergasa, N. V. (1993) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1993.tb17167.x · Cited by 2
Preventative therapy in primary biliary cirrhosis
Floreani, A. (2003) · Clinics in Liver Disease · doi:10.1016/s1089-3261(03)00094-1 · Cited by 2
Primary biliary cirrhosis in Lithuania: diagnosis and clinical picture.
Speičienė, D., Irnius, A., Leuschner, U., Liakina, V., Semuchiniene, T., & Barakauskienė, A. (2007) · PubMed · Cited by 2
Levy, C., Carrion, A. F., & Mayo, M. J. (2017) · Wiley eBooks · doi:10.1002/9781119251316.ch21 · Cited by 2
Cyclosporin A for primary biliary cirrhosis
Gong, Y., Christensen, E., & Gluud, C. N. (2005) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005526 · Cited by 2
Yahia, A., Baker, F. A., Tatour, M., & Hazzan, R. (2025) · Annals of Hepatology · doi:10.1016/j.aohep.2025.102147 · Cited by 1
Romeo, M., Nardo, F. D., Basile, C., Napolitano, C., Vaia, P., Martinelli, G., Gregorio, A. D., Puorto, L. D., Indipendente, M., Dallio, M., et al. (2025) · Journal of Personalized Medicine · doi:10.3390/jpm15120597 · Cited by 2
Primary Biliary Cholangitis: Its Science and Practice
Wang, L., Bowlus, C. L., Wang, F., & Gershwin, M. E. (2017) · Springer eBooks · doi:10.1007/978-3-319-50168-0_8 · Cited by 1
Heathcote, E. J., & Milkiewicz, P. (2007) · Wiley eBooks · doi:10.1002/9780470691861.ch11a · Cited by 1
(1995) · Elsevier eBooks · doi:10.1016/b978-012552110-9/50010-6 · Cited by 1
Primary Sclerosing Cholangitis
Nguyen, D. L., LaRusso, N. F., & Lazaridis, K. N. (2011) · doi:10.1002/9781119950509.ch20 · Cited by 1
Hepatopatías colestásicas del adulto
Palau, A., & Berenguer, J. (2008) · Elsevier eBooks · doi:10.1016/b978-84-8086-310-0.50034-8
Gender-Specific Issues in Liver Diseases
Conjeevaram, H. S. (2004) · Principles of Gender-Specific Medicine · doi:10.1016/b978-012440905-7/50312-1
Carcinome hépatocellulaire sur cirrhose biliaire primitive asymptomatique
Lucidarme, D., Vandermolen, P., Khattab, H., Catala, P., Bahon Le Capon, J., Creusy, C., & Filoche, B. (1996) · La Revue de Médecine Interne · doi:10.1016/0248-8663(96)83094-3
Bile acid and immunosuppressive therapy in primary biliary cirrhosis
Wolfhagen, F. (1995) · RePub (Erasmus University Rotterdam)
Primär biliäre Zirrhose: Diagnostik und Therapie
Schönfeld, J. V., Breuer, N. F., & Goebell, H. (1998) · Medizinische Klinik - Intensivmedizin und Notfallmedizin · doi:10.1007/bf03042679
Cholestatische Lebererkrankungen: Diagnostik und Therapie der primär biliären Zirrhose
Thimme, R., Opitz, O., & Kreisel, W. (2002) · DMW - Deutsche Medizinische Wochenschrift · doi:10.1055/s-2002-33861 · Cited by 2
Torok, N. J., & Lindor, K. (2004) · Encyclopedia of Gastroenterology · doi:10.1016/b0-12-386860-2/00131-3
Self-citationKakimoto, H., Kawata, S., Imai, Y., Tamura, S., Inada, M., Inui, Y., Matsuda, Y., Ito, N., Takaishi, K., Fukuda, K., et al. (1991) · Acta gastro-enterologica belgica · doi:10.11280/gee1973b.33.2445
Carey, E. J., & Levy, C. (2018) · Clinics in Liver Disease · doi:10.1016/s1089-3261(18)30044-8
James, S. P. (2011) · Wiley eBooks · doi:10.1002/9781119950509.ch21
Natural history and demography of primary biliary cirrhosis
James, O. (1998) · Springer eBooks · doi:10.1007/978-94-011-4884-9_1
Prognosis of autoimmune liver diseases
Boberg, K. M., & Schrumpf, E. (2007) · Springer eBooks · doi:10.1007/1-4020-2914-4_22
Cholangitis and cholangiodysplasia
(2006) · Springer eBooks · doi:10.1007/3-540-28977-1_32
Intrahepatische Gallenwegserkrankungen
Evert, M. (2020) · Pathologie · doi:10.1007/978-3-642-04557-8_9
Kuntz, E., & Kuntz, H.-D. (2002) · Springer eBooks · doi:10.1007/978-3-662-04680-7_32
Primary biliary cholangitis, a rising health burden
Elnaggar, M., Elkhattib, I., Abomhya, A., & Boyer, J. L. (2024) · Exploration of Immunology · doi:10.37349/ei.2024.00165
Chung, A. H.-L., Tan, J. J.-R., Yap, R. X. J., Loo, J. H., Tay, W. X., Singh, C. L., Ong, S. J., Low, A. Y. J., Lin, Y., Lytvyak, E., et al. (2026) · Hepatology Communications · doi:10.1097/hc9.0000000000000940
Pharmacological Treatment of Primary Biliary Cirrhosis
Roda, E., Pezzoli, A., Fusaroli, P., Fabbri, C., Accogli, E., Ciriaci, A. M., Cipolla, A., & Mazzella, G. (1996) · Springer eBooks · doi:10.1007/978-94-009-0357-9_34
Metadata
- Authors
- Balasubramaniam, K., Grambsch, P. M., Wiesner, R. H., Lindor, K. D., & Dickson, E. R.
- Affiliations
- Mayo Clinic (US)
- ORCID
- Lindor, Keith D.
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 1990-06
- Volume
- 98
- Issue
- 6
- Pages
- 1567-1571
- ISSN
- 0016-5085 (ISSN-L)
- OpenAlex
- W140612521
- Cited by
- 141
- References
- 24
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 1 · 2018: 7 · 2017: 5 · 2016: 1 · 2014: 1 · 2013: 1 · 2012: 3
- FWCI
- 4.06
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (DK34238 02, R01DK034238)
- Topics
- Health Sciences › Medicine › Hepatology › Liver Diseases and Immunity
- Health Sciences › Medicine › Surgery › Pediatric Hepatobiliary Diseases and Treatments
- Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
- Keywords
- primary biliary cirrhosis, asymptomatic patients, long-term survival, mortality, D-penicillamine, disease progression, esophageal varices, liver failure, serum albumin, serum bilirubin, liver transplantation
- MeSH terms
- Adult, Aged, Bilirubin, Female, Follow-Up Studies, Humans, Liver, Liver Cirrhosis, Biliary, Male, Middle Aged, Penicillamine, Prospective Studies, Serum Albumin, Survival Rate
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