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Cited by 235Liver Diseases and ImmunityDrug Transport and Resistance MechanismsPediatric Hepatobiliary Diseases and Treatments

The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.

Effects of long-term rifampicin administration in primary biliary cirrhosis

Open access
Bachs, Laura, Parés, Albert, Elena, Montserrat, Piera, Carlos, Rodés, Joan·1992·Gastroenterology
DOI 10.1016/0016-5085(92)90335-v
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Abstract

The effects of rifampicin treatment (10 mg.kg-1.day-1) on pruritus and cholestasis were evaluated in 16 patients with primary biliary cirrhosis and pruritus followed up for 2-24 months. Assessment of pruritus severity, liver tests, aminopyrine breath test, and bile acids was done at 2 weeks and every 3 months after the beginning of the study. Two patients (12.5%) were withdrawn after 2 months of treatment because they had hepatitis caused by rifampicin. Four patients were withdrawn after 4 months because of liver transplantation (3 cases) and the development of leg edema associated with administration of rifampicin. The remaining 10 patients received therapy for 14.4 +/- 0.7 months and did not experience side effects. Pruritus improved in all patients and disappeared in 11 patients (79%) after 3 months of treatment. Moreover, all patients followed up for more than 1 year were free of pruritus. The alkaline phosphatase level decreased significantly, and the aminopyrine breath test results increased significantly after 2 weeks of treatment (P less than 0.001) and did not change thereafter. In the 9 patients treated for 15 months, alkaline phosphatase levels decreased to 63% of the basal levels and aminopyrine breath test results increased to 153% of baseline values. Transaminases, gamma-glutamyltransferase, and total bile salt levels decreased significantly after 2 weeks of treatment but returned to baseline after 3 months. No changes in bilirubin and cholesterol levels were observed. It is concluded that long-term rifampicin treatment is effective for relieving pruritus in primary biliary cirrhosis, but liver enzymes should be monitored to detect drug-induced hepatitis.

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Crossref · 10.1016/0016-5085(92)90335-v

Cites

24 of 24 references verified0 citation errors · 0 not checkable

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Citations

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Research works printed but not linked: 2

  1. Pérez-Ayuso, 1980, Effect of phenobarbital treatment on pruritus and hepatic excretory function in primary biliary cirrhosis (abstr), Gastroenterology, 79, 1119
  2. Quintero, 1986, Utilidad del recambio plasmático intermitente en la cirrosis biliar primaria, Gastroenterol Hepatol, 9, 329

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Metadata

Authors
Bachs, L., Parés, A., Elena, M., Piera, C., & Rodés, J.
Affiliations
Hospital Clínic de Barcelona (ES)
ORCID
Parés, Albert
Venue
Gastroenterology
Publisher
Elsevier BV
Published
1992-06
Volume
102
Issue
6
Pages
2077-2080
ISSN
0016-5085 (ISSN-L)
DOI
10.1016/0016-5085(92)90335-v
OpenAlex
W1219313770
Cited by
235
References
24
Citations by year
2026: 4 · 2025: 3 · 2024: 8 · 2023: 5 · 2022: 7 · 2021: 5 · 2020: 6 · 2019: 8 · 2018: 10 · 2017: 9 · 2016: 7 · 2015: 12 · 2014: 8 · 2013: 5 · 2012: 7
FWCI
1.83
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Gastroenterology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Hepatology › Liver Diseases and Immunity
  • Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
  • Health Sciences › Medicine › Surgery › Pediatric Hepatobiliary Diseases and Treatments
Keywords
rifampicin, primary biliary cirrhosis, pruritus, cholestasis, drug-induced hepatitis, aminopyrine breath test, alkaline phosphatase, bile acids, long-term drug therapy, adverse drug reactions
MeSH terms
Bile Acids and Salts, Cholestasis, Female, Humans, Liver, Liver Cirrhosis, Biliary, Middle Aged, Pruritus, Rifampin

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