Increased serum deoxycholic acid levels in men with colorectal adenomas
Abstract
Background Epidemiological and animal studies have suggested that the secondary bile acid deoxycholic acid is cocarcinogenic in colorectal cancer, but this hypothesis was not confirmed by case-control studies investigating fecal bile acids.Methods Individual serum bile acid concentrations were investigated in 25 men and 25 women with colorectal adenomas and in an equal number of age- and sex-matched controls by gas-liquid chromatography.Results Deoxycholic acid levels were significantly higher in the sera of men with colorectal adenomas (1.70 +/- 0.59 vs. 1.16 +/- 0.39 mumol/L, P < 0.0005) and in a combined analysis of both sexes (1.47 +/- 0.78 vs. 1.08 +/- 0.39 mumol/L, P < 0.0025). Six- and 12-month follow-up measurements of deoxycholic acid concentrations in a subgroup of 22 men and 17 women showed higher serum levels in men with adenomas, indicating that measurement of deoxycholic acid concentration may be a reliable parameter to investigate its pathogenetic role in colonic neoplasia.Conclusions The data of this study support the hypothesis that deoxycholic acid may play a role in the pathogenesis of colorectal cancer.
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In patients with colorectal adenomas, circulating deoxycholic acid levels were higher than in controls in studies from the 1990s.
“Studies in the 1990s reported higher circulating levels of deoxycholic acid in patients with colorectal adenomas than controls.156, 157”
From Influence of the Gut Microbiome, Diet, and Environment on Risk of Colorectal Cancer (2020) · cites this paper as [157]
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References 60 · Cited by 234
- Authors
- Bayerdörffer, E., Mannes, G. A., Richter, W. O., Ochsenkühn, T., Wiebecke, B., Köpcke, W., & Paumgartner, G.
- Affiliations
- Pathologisches Institut (DE)
- Ludwig-Maximilians-Universität München (DE)
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 1993-01
- Volume
- 104
- Issue
- 1
- Pages
- 145-151
- ISSN
- 0016-5085 (ISSN-L)
- OpenAlex
- W1079775
- Cited by
- 234
- References
- 60
- Citations by year
- 2026: 2 · 2025: 8 · 2024: 13 · 2023: 4 · 2022: 16 · 2021: 12 · 2020: 5 · 2019: 7 · 2018: 8 · 2017: 6 · 2016: 7 · 2015: 5 · 2014: 7 · 2013: 5 · 2012: 7
- FWCI
- 3.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Colorectal Cancer Screening and Detection
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Keywords
- deoxycholic acid, serum bile acids, colorectal adenoma, colorectal cancer, secondary bile acids, colonic neoplasia, sex differences, cancer risk biomarkers
- MeSH terms
- Adenoma, Adult, Aged, Bile Acids and Salts, Deoxycholic Acid, Female, Follow-Up Studies, Humans, Male, Middle Aged, Osmolar Concentration, Reference Values, Sex Characteristics, Colorectal Neoplasms
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