Predominant symptoms in irritable bowel syndrome correlate with specific autonomic nervous system abnormalities
Open accessAbstract
Background/aims Irritable bowel syndrome may be influenced by the autonomic nervous system. Abnormalities in autonomic function, colon transit time, and psychological profiles in 21 patients were assessed.Methods Using modified Manning criteria for irritable bowel syndrome, patients were classified as constipation-predominant or diarrhea-predominant. Autonomic function was determined by one vagal cholinergic and two sympathetic adrenergic measures. Colon transit was assessed by radiopaque markers, and psychological profiles were determined by three inventories.Results Autonomic function tests showed that diarrhea-predominant subgroup values for one sympathetic adrenergic measure (postural adjustment ratio) were significantly different from controls (P < 0.01). Constipation-predominant subgroup values were significantly lower for the vagal cholinergic measure R-R interval (P < 0.05). Colon transit measures differed by subgroup in left, right, rectosigmoid, and total colon transit times. Both subgroups differed significantly from controls on psychological measures; the constipation subgroup showed more psychological distress.Conclusions Irritable bowel syndrome specific-symptom subgroups had different patterns of autonomic functioning, colonic transit, and psychological measures. The constipation subgroup is associated with a cholinergic abnormality and the diarrhea-predominant subgroup with an adrenergic abnormality. These findings suggest specific associations between the autonomic nervous system, predominant physical symptoms, colon transit time, and psychological factors in patients with irritable bowel syndrome.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Activation of the HPA axis in individuals with irritable bowel syndrome (IBS) without ASD is associated with an augmented adrenocorticotropic hormone (ACTH) and cortisol response, as well as increased sympathetic activity and low vagal tone.
“Activation of the HPA axis in individuals with irritable bowel syndrome (IBS) without ASD is associated with an augmented adrenocorticotropic hormone (ACTH) and cortisol response, as well as increased sympathetic activity and low vagal tone (Aggarwal et al., 1994; Mayer, 2000).”
From Associations between cytokines, endocrine stress response, and gastrointestinal symptoms in autism spectrum disorder (2016) · cites this paper as Aggarwal et al., 1994
Increased intestinal permeability is a critical event in the onset of clinical symptoms of GI disorders including IBS and IBD.
“a critical event in the onset of clinical symptoms of GI disorders including irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD) [7], [8], [9], [10]”
From CRF induces intestinal epithelial barrier injury via the release of mast cell proteases and TNF-α (2012) · cites this paper as [7]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
The citation lists haven’t been fetched yet
References 23 · Cited by 297
Research works printed but not linked: 3
- Thompson WG, Dotevall G, Drossman DA, Heaton KW, Kruis W. Irritable bowel syndrome: guidelines for the diagnosis. Gastroen- terol Int 1989;2:92-95.
- Abell TL, Murphy W, Wilson R, Schwartzbaum J, Familoni B, Car- doso S, Massie D. The role of the Minnesota Multiphasic Person- ality Inventory in the evaluation of patients with upper gut dysmo- tility (abstr). Gastroenterology 1988;94:A2.
- Swenson WM, Pearson JS, Osborne D. An Minnesota Multiphasic Personality Inventory source book: basic item, scale, and pattern data on 50,000 medical patients. Minneapolis: University of Min- nesota, 1973.
- Authors
- Aggarwal, A., Cutts, T. F., Abell, T. L., Cardoso, S., Familoni, B., Bremer, J., & Karas, J.
- Affiliations
- University of Tennessee Health Science Center (US)
- Baptist Memorial Hospital (US)
- University of Memphis (US)
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 1994-04
- Volume
- 106
- Issue
- 4
- Pages
- 945-950
- ISSN
- 0016-5085 (ISSN-L)
- OpenAlex
- W1833774496
- Cited by
- 297
- References
- 23
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 4 · 2023: 3 · 2022: 2 · 2021: 9 · 2020: 3 · 2019: 3 · 2018: 6 · 2017: 5 · 2016: 7 · 2015: 8 · 2014: 9 · 2013: 11 · 2012: 15
- FWCI
- 4.66
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Center for Research Resources (M01RR000211, M01 RR00211-23)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Health Professions › Pharmacy › Infant Health and Development
- Keywords
- irritable bowel syndrome, irritable bowel syndrome with constipation, diarrhea-predominant irritable bowel syndrome, autonomic nervous system, cholinergic dysfunction, adrenergic dysfunction, colonic transit time, psychological distress, RR interval, Manning criteria
- MeSH terms
- Adult, Aged, Autonomic Nervous System, Autonomic Nervous System Diseases, Colonic Diseases, Functional, Constipation, Diarrhea, Female, Gastrointestinal Transit, Humans, Male, Middle Aged, MMPI, Prospective Studies
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
