Role for prenatal estrogen in the development of masculine sexual behavior in the male ferret
Abstract
Previous studies have shown that neonatal exposure to testosterone is essential for coital masculinization in male ferrets. In the present experiments, masculine sexual behavior was diminished in male ferrets by prenatal exposure to drugs which inhibited estrogenic stimulation of the brain. Similarly timed prenatal treatments with testosterone failed to masculinize the behavior of female offspring. We hypothesize that prenatal exposure of the male ferret to estrogen, derived from the neural aromatization of circulating androgen, may sensitize the developing brain to the subsequent masculinizing action of testosterone shortly after birth.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Brief exposure to elevated androgens late in gestation sensitizes the developing male to androgen exposure during the neonatal period.
“Several studies have suggested that this brief expo- sure to elevated androgens late in gestation sensitizes the developing male to androgen exposure during the neonatal period (Baum et al. 1990; Hoepfner and Ward 1988; Tobet and Baum 1987).”
From Androgens and environmental antiandrogens affect reproductive development and play behavior in the Sprague-Dawley rat. (2002) · cites this paper as Tobet and Baum 1987
Cited by
Sorted by citations
Hotchkiss, A. K., Ostby, J. S., Vandenburgh, J. G., & Gray, L. E. (2002) · Environmental Health Perspectives · doi:10.1289/ehp.02110s3435 · Cited by 82 · see citing works
- Authors
- Tobet, S. A., & Baum, M. J.
- Affiliations
- Massachusetts Institute of Technology (US)
- Corresponding author
- Baum, M.J.
- Venue
- Hormones and Behavior
- Publisher
- Elsevier BV
- Published
- 1987-12
- Volume
- 21
- Issue
- 4
- Pages
- 419-429
- ISSN
- 0018-506X (ISSN-L)
- OpenAlex
- W1979513598
- Cited by
- 53
- References
- 0
- Citations by year
- 2019: 1 · 2018: 2 · 2017: 1 · 2016: 1 · 2014: 2 · 2013: 1
- FWCI
- 0.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hormones and Behavior (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (MH-08937, MH-00392)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD21094)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Keywords
- testosterone, aromatization, sexual differentiation of the brain, neonatal testosterone, sex differences in behavior, female offspring
- MeSH terms
- Androstatrienes, Animals, Carnivora, Estradiol, Estrogens, Female, Ferrets, Hypothalamus, Male, Ovariectomy, Pregnancy, Prenatal Exposure Delayed Effects, Preoptic Area, Sexual Behavior, Animal, Testosterone, Aromatase Inhibitors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
