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Cited by 103Porphyrin Metabolism and DisordersPorphyrin and Phthalocyanine ChemistryPhotodynamic Therapy Research Studies

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Heme biosynthesis in human breast cancer—mimetic “in vitro” studies and some heme enzymic activity levels

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Navone, Nora M., Polo, Cesar F., Frisardi, Alberto L., Andrade, Nelida E., del C. Baille, alcira M.·1990·International Journal of Biochemistry
DOI 10.1016/0020-711x(90)90230-z
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Abstract

1. Porphyrin biosynthesis from delta-aminolevulinic acid (ALA) was investigated using the technique of tissue explant cultures, in both human breast cancer and its original normal tissue. 2. The activity of ALA-dehydratase, porphobilinogenase and uroporphyrinogen decarboxylase was directly determined in both tumor and normal mammary tissues. 3. Porphyrin synthesis capacity of human breast carcinoma was 20-fold enhanced, as compared with normal tissue, at least between the stages of porphobilinogen and coproporphyrinogen formation. 4. The activity of the three enzymes examined was always lower in normal tissue than in tumoral tissue. 5. Present findings show that porphyrin biosynthesis is increased in breast cancer tissue.

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Crossref · 10.1016/0020-711x(90)90230-z

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  • Enhanced activity of enzymes leading to production of PpIX, such as ALAD, UROD, or PBGD, has been observed in tumor cells.

    “Enhanced activity of enzymes leading to production of PpIX, such as ALAD [43], UROD [43], or PBGD [38,43,44] has also been observed in tumor cells.”

    From Aminolevulinic Acid (ALA) as a Prodrug in Photodynamic Therapy of Cancer (2011) · cites this paper as [43]

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References 28 · Cited by 103

Research works printed but not linked: 28

  1. Batlle, 1967, Purification and general properties of δ-aminolevulinate dehydratase from cow liver, Biochem. J., 194, 244, 10.1042/bj1040244 · DOI
  2. Batlle, 1978, A simple method for measuring erythrocyte porphobilinogenase and its use in the diagnosis of acute intermittent porphyria, Int. J. Biochem, 9, 871, 10.1016/0020-711X(78)90062-9 · DOI
  3. Bonkowsky, 1973, Control of 5-aminolevulinic acid synthetase and tyrosine aminotransferase in tumors and livers of tumorbearing rats, J. natn. Cancer Inst., 50, 1215, 10.1093/jnci/50.5.1215 · DOI
  4. Bugelski, 1981, Autoradiographic distribution of hematoporphyrin derivatives in normal and tumor tissue of the mouse, Cancer Res, 41, 4606
  5. Buzaleh, 1988, Induction of porphyrin biosynthesis in the non-animal model of tissue expiant cultures: prevention and reversal by the antimitotic colchicine, ATLA, 16, 137
  6. Denk, 1980, Microsomal mixed-function oxidase and activities of some related enzymes in hyperplastic nodules induced by long-term griseofulvin administration in mouse liver, Cancer Res., 40, 2568
  7. Dougherty, 1978, Photoradiation therapy for the treatment of malignant tumors, Cancer Res., 38, 2628
  8. Dougherty, 1979, Photoradiation in the treatment of recurrent breast carcinoma, J. natn. Cancer Inst., 62, 231
  9. Farber, 1984, Cellular biochemistry of the stepwise development of cancer with chemicals. GHA Clowes Memorial Lecture, Cancer Res., 44, 5463
  10. Gomer, 1979, Determination of 3H- and 14C-hematoporphyrin derivative distribution in malignant and normal tissue, Cancer Res., 39, 146
  11. Gregorie, 1968, Hematoporphyrin derivative fluorescence in malignant neoplasms, Ann. Surg, 167, 820, 10.1097/00000658-196806000-00002 · DOI
  12. Jori, 1986, Controlled targeting of different subcellular sites by protoporphyrins in tumor-bearing mice, Br, J. Cancer, 53, 615, 10.1038/bjc.1986.104 · DOI
  13. Kessel, 1981, Transport and binding of hematoporphyrin derivative and related porphyrins by murine leukemia L 1210 cells, Cancer Res., 41, 1318
  14. Lahav, 1987, Increased porphobilinogen deaminase activity in patients with malignant lymphoproliferative diseases, J. Am. Med. Assoc., 257, 39, 10.1001/jama.1987.03390010043025 · DOI
  15. Lipson, 1961, The use of derivative of hematoporphyrin in tumor detection, J. naln. Cancer Inst., 26, 1
  16. Lowry, 1951, Protein measurement with the folin phenol reagent, J. biol. Chem., 193, 265, 10.1016/S0021-9258(19)52451-6 · DOI
  17. Navone, 1988, Porphyrin biosynthesis in human breast cancer. Preliminary mimetic in vitro studies, Med. Sci. Res., 16, 61
  18. Navone, 1990, Heme regulation in mouse mammary carcinoma and liver of tumor bearing mice. 1. Effect of allylisopropylacetamide and veronal on °5-aminolevulinate synthetase, cytochrome P-450 and cytochrome oxidase, Int. J. Biochem., 22, 1005, 10.1016/0020-711X(90)90207-J · DOI
  19. Polo, 1988, Factors influencing fluorescence spectra of free porphyrins, Clin. Chem., 34, 757, 10.1093/clinchem/34.4.757 · DOI
  20. Polo, 1990, Un método para la medición de la actividad enzimática de la uroporfirinógeno decarboxilasa en sangre, Acta Bioquim. Clin. Latinoamer.
  21. Rasetti, 1967, Ferrochelatase, ALA-dehydrase and ALA-synthetase activity in human tumor disease, PanMinerva Med., 8, 132
  22. Rassrnussen-Taxdall, 1955, Fluorescence of human lymphatic and cancer tissues following high doses of intravenous hematoporphyrin, Cancer, 8, 78, 10.1002/1097-0142(1955)8:1<78::AID-CNCR2820080109>3.0.CO;2-L · DOI
  23. Sandberg, 1981, Porphyrin-induced photodamage at the cellular and subcellular level as related to the solubility of the porphyrin, Clinica chim. acta, 109, 193, 10.1016/0009-8981(81)90334-X · DOI
  24. Stout, 1986, Heme enzyme patterns in genetically and chemically induced mouse liver tumors, Cancer Res., 46, 2756
  25. Stout, 1987, Heme enzyme patterns in rat liver nodules and tumors, Cancer Res., 47, 963
  26. Takaku, 1968, Heme synthesis in normal and leukemic leukocytes, Cancer Res., 28, 1250
  27. Vázquez, 1986, Cultivo de explantes tisulares. II. Grado de lisis y su protección por el ácido δ-aminolevúlico, An. Med. Inter. (Madrid), 111, 258
  28. Vázquez, 1987, The effect of griseofulvin on heme pathway. Studies on tissue explant cultures, Toxicology, 46, 73, 10.1016/0300-483X(87)90139-9 · DOI

Metadata

Authors
Navone, N. M., Polo, C. F., Frisardi, A. L., Andrade, N. E., & del C. Baille, A. M.
Affiliations
Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
ORCID
Navone, Nora M.
Venue
International Journal of Biochemistry
Publisher
Elsevier BV
Published
1990-01
Volume
22
Issue
12
Pages
1407-1411
ISSN
0020-711X (ISSN-L)
DOI
10.1016/0020-711x(90)90230-z
OpenAlex
W2032803546
Cited by
103
References
28
Citations by year
2026: 2 · 2025: 2 · 2024: 1 · 2023: 4 · 2022: 3 · 2021: 3 · 2020: 5 · 2019: 3 · 2018: 3 · 2017: 5 · 2016: 1 · 2015: 5 · 2014: 3 · 2012: 2
FWCI
0.70
Type
journal article
Language
en
Open access
Licence
Locations
  • International Journal of Biochemistry (publishedVersion)
  • PubMed (publishedVersion)
  • Repositorio Digital Institucional de la Universidad de Buenos Aires (Universidad de Buenos Aires) (publishedVersion, other-oa)
  • LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
  • Greater South Information System
Funders
Consejo Nacional de Investigaciones Científicas y Técnicas
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Porphyrin Metabolism and Disorders
  • Physical Sciences › Materials Science › Materials Chemistry › Porphyrin and Phthalocyanine Chemistry
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Photodynamic Therapy Research Studies
Keywords
heme biosynthesis, breast cancer, porphyrin synthesis, 5-aminolevulinic acid, delta-aminolevulinic acid dehydratase, uroporphyrinogen decarboxylase, explant culture, enzyme activity
MeSH terms
Adult, Aged, Porphobilinogen Synthase, Ammonia-Lyases, Breast, Breast Neoplasms, Female, Heme, Humans, Middle Aged, Uroporphyrinogen Decarboxylase, Culture Techniques

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