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The formation of internal 6-methyladenine residues in eucaryotic messenger rna

Tuck, Martin T.·1992·International Journal of Biochemistry
DOI 10.1016/0020-711x(92)90028-y
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Abstract

1. The formation of internal 6-methyladenine (m6A) residues in eucaryotic messenger RNA (mRNA) is a postsynthetic modification in which S-adenosyl-L-methionine (SAM) serves as the methyl donor. 2. Of the methyl groups incorporated into mature mRNA 30-50% occur in m6A residues. 3. Although most cellular and certain viral mRNAs contain at least one m6A residue, some transcripts such as those coding for histone and globin are completely lacking in this modification. 4. 6-Methyladenine residues have also been localized to heterogeneous nuclear RNA (HnRNA), and for the most part these residues are conserved during mRNA processing. 5. In all known cases, the m6A residues are also found in a strict consensus sequence, Gm6AC or Am6AC, within the transcript. 6. Although the biological significance of internal adenine methylation in eucaryotic mRNA remains unclear, a great deal of research has indicated that this modification may be required for mRNA transport to the cytoplasm, the selection of splice sites or other RNA processing reactions.

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Research works printed but not linked: 52

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Metadata

Authors
Tuck, M. T.
Venue
International Journal of Biochemistry
Publisher
Elsevier BV
Published
1992-03
Volume
24
Issue
3
Pages
379-386
ISSN
0020-711X
DOI
10.1016/0020-711x(92)90028-y
Cited by
57
References
0
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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CoChat. (2026). Citation check: The formation of internal 6-methyladenine residues in eucaryotic messenger rna. https://app.cochat.ai/papers/10.1016/0020-711x(92)90028-y
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Tuck, M. T. (1992). The formation of internal 6-methyladenine residues in eucaryotic messenger rna. International Journal of Biochemistry. https://doi.org/10.1016/0020-711x(92)90028-y

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