Metabolism of apolipoprotein C–I in normolipoproteinemic human subjects
Abstract
Labeling of apolipoprotein C-I by the Bolton and Hunter reagent allowed a study of the kinetics of this peptide in normolipidemic human volunteers. After its intravenous injection the appearance of radioactivity of the labeled apoprotein was followed in plasma, lipoprotein fractions, and urine for 15 days. Apolipoprotein C-I was quickly associated with HDL and to a smaller extent with VLDL in in vitro and in vivo incubation. Kinetic parameters of apolipoprotein C-I were compared with those of apo A-I. Fractional catabolic rates are respectively 0.422 +/- 0.044 vs 0.240 +/- 0.003 pools/day, residence times through the whole system 3.24 +/- 0.27 vs 6.31 +/- 0.27 days and production rates 1.79 +/- 0.18 vs 13.2 +/- 2.1 mg/kg X day. Two explanations for these differences are proposed.
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In the previous apoC-I kinetic study by Malmendier et al., for four NL subjects, apoC-I TR was 1.8 mg/kg/day and RT was 3.2 days.
“More than 80% of injected 125 I-BH-apoC-I was found associated in plasma with HDL (38), and for four NL subjects, apoC-I TR was determined to be 1.8 mg•kg Ϫ1 •day Ϫ1 and RT was 3.2 days, which compares to 0.9 Ϯ 0.1 mg•kg Ϫ1 •day Ϫ1 and 3.7 Ϯ 0.3 days, respectively, in the present study.”
From Plasma turnover of HDL apoC-I, apoC-III, and apoE in humans (2003) · cites this paper as [38]
The present study's HDL apoC-I TR (0.9 ±0.1 mg/kg/day) and RT (3.7 ±0.3 days) compare well with the previous apoC-I kinetic study.
“More than 80% of injected 125 I-BH-apoC-I was found associated in plasma with HDL (38), and for four NL subjects, apoC-I TR was determined to be 1.8 mg•kg Ϫ1 •day Ϫ1 and RT was 3.2 days, which compares to 0.9 Ϯ 0.1 mg•kg Ϫ1 •day Ϫ1 and 3.7 Ϯ 0.3 days, respectively, in the present study.”
From Plasma turnover of HDL apoC-I, apoC-III, and apoE in humans (2003) · cites this paper as [38]
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Plasma turnover of HDL apoC-I, apoC-III, and apoE in humans
Cohn, J. S., Batal, R., Tremblay, M., Jacques, H., Veilleux, L., Rodriguez, C., Mamer, O., & Davignon, J. (2003) · Journal of Lipid Research · doi:10.1194/jlr.m300209-jlr200 · Cited by 35 · see citing works
- Authors
- MALMENDIER, C., LONTIE, J., GRUTMAN, G., & DELCROIX, C.
- Affiliations
- Université Libre de Bruxelles (BE)
- Venue
- Atherosclerosis
- Publisher
- Elsevier BV
- Published
- 1986-11
- Volume
- 62
- Issue
- 2
- Pages
- 167-172
- ISSN
- 0021-9150 (ISSN-L)
- OpenAlex
- W1995590649
- Cited by
- 27
- References
- 0
- Citations by year
- 2025: 1 · 2024: 2 · 2022: 1 · 2021: 1 · 2018: 1 · 2015: 1 · 2014: 1 · 2012: 1
- FWCI
- 2.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Atherosclerosis (publishedVersion)
- PubMed (publishedVersion)
- Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Keywords
- apolipoprotein C-I, apolipoprotein A-I, apolipoprotein metabolism, fractional catabolic rate, residence time, production rate, HDL cholesterol, VLDL, lipoprotein binding, normolipidemic subjects
- MeSH terms
- Adult, Apolipoproteins A, Apolipoproteins C, Female, Humans, Iodine Radioisotopes, Kinetics, Lipoproteins, Lipoproteins, HDL, Lipoproteins, VLDL, Male, Metabolic Clearance Rate, Reference Values, Apolipoprotein A-I, Apolipoprotein C-I
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