Arrangement of nucleotide sequences in adeno-associated virus DNA
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The maximum packaging capacity of members of the Parvoviridae family is approximately 4.5-5.5 kb.
“This suggests that the maximum packaging capacity of members of the Parvoviridae family is approximately 4.5-5.5 kb.”
From Expressing Transgenes That Exceed the Packaging Capacity of Adeno-Associated Virus Capsids (2016) · cites this paper as [20]
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Expressing Transgenes That Exceed the Packaging Capacity of Adeno-Associated Virus Capsids
Chamberlain, K., Riyad, J. M., & Weber, T. (2016) · Human Gene Therapy Methods · doi:10.1089/hgtb.2015.140 · Cited by 141 · see citing works
- Authors
- Gerry, H. W., Kelly, T. J., & Berns, K. I.
- Affiliations
- Johns Hopkins University (US)
- ORCID
- Kelly, Thomas J.
- Venue
- Journal of Molecular Biology
- Publisher
- Elsevier BV
- Published
- 1973-09
- Volume
- 79
- Issue
- 2
- Pages
- 207-225
- ISSN
- 0022-2836 (ISSN-L)
- OpenAlex
- W1984435631
- Cited by
- 69
- References
- 0
- Citations by year
- 2020: 1 · 2016: 1 · 2014: 1
- FWCI
- 6.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Molecular Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
- Health Sciences › Medicine › Infectious Diseases › Parvovirus B19 Infection Studies
- Keywords
- adeno-associated virus, viral DNA structure, single-stranded DNA, DNA annealing, circular permutation, exonuclease III, DNA termini, terminal repeats
- MeSH terms
- Adenoviridae, Base Sequence, Carbon Radioisotopes, Carcinoma, Cell Line, Centrifugation, Density Gradient, DNA, Circular, DNA, Single-Stranded, DNA, Viral, Escherichia coli, Exonucleases, Humans, Microscopy, Electron, Molecular Weight, Mouth Neoplasms, Nucleic Acid Conformation, Nucleic Acid Denaturation, Nucleic Acid Renaturation, Phosphorus Radioisotopes, Satellite Viruses, Spectrophotometry, Ultraviolet, Thymidine, Tritium
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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