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Development of myelinated and unmyelinated fibers of human vagus nerve during the first year of life
Abstract
As an important component of cardiorespiratory control, the vagus nerve and its maturation were evaluated in normal infants in order to provide standards of comparison with infants with dysfunctional neural control mechanisms. Myelinated and unmyelinated fibers in the cervical vagus nerve were examined in 27 term infants. Number of fibers, axon diameters, and myelin thickness were compared among four age groups. The histograms of axon size exhibited a skewed distribution that persisted during the age range examined for both myelinated and unmyelinated vagus fibers. Fiber size distributions of myelinated fibers, however, already showed an incipient multimodal distribution after 3 months. No major increase was observed in the average axon size of myelinated and unmyelinated fibers. A significant increase was observed, however, in the average content of myelin in myelinated fibers expressed as myelin thickness, number of lamellae or g ratio (internal/external diameter). These results suggest an active myelination during the first 9 months of life without a major change in the axonal characteristics of the fibers. A marginal increase in the density of myelinated fibers with age, both in terms of total number and the relation to unmyelinated fibers, suggests a slow transition from unmyelinated to myelinated fibers during the first year of life, particularly during the first 3 months. The present morphometric parameters indicate an active deposition of myelin before the maturation…
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Autopsy data confirm a developmental increase in the number and ratio of myelinated vagal fibers.
“Autopsy data [45,46] confirm a developmental increase in the number and ratio of myelinated vagal fibers.”
From The vagal paradox: A polyvagal solution (2023) · cites this paper as [46]
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Research works printed but not linked: 16
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The vagal paradox: A polyvagal solution
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“Autopsy data [45,46] confirm a developmental increase in the number and ratio of myelinated vagal fibers.”
Background
Metadata
- Authors
- Pereyra, P. M., Zhang, W., Schmidt, M., & Becker, L. E.
- Affiliations
- Hospital for Sick Children (CA)
- University of Toronto (CA)
- Venue
- Journal of the Neurological Sciences
- Publisher
- Elsevier BV
- Published
- 1992-07
- Volume
- 110
- Issue
- 1-2
- Pages
- 107-113
- ISSN
- 0022-510X (ISSN-L)
- OpenAlex
- W2077828779
- Cited by
- 59
- References
- 0
- Citations by year
- 2024: 2 · 2023: 7 · 2022: 9 · 2021: 6 · 2020: 2 · 2019: 3 · 2018: 2 · 2017: 3 · 2015: 3 · 2014: 1 · 2012: 3
- FWCI
- 0.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the Neurological Sciences (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01hd022713-04)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD22713)
- Topics
- Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Anatomy › Classical Anatomy and Histology
- Keywords
- vagus nerve, myelination, unmyelinated nerve fibers, myelinated axons, axon diameter, myelin thickness, g-ratio, infancy, cervical vagus nerve, conduction velocity, cardiorespiratory control
- MeSH terms
- Aging, Axons, Humans, Infant, Infant, Newborn, Nerve Fibers, Nerve Fibers, Myelinated, Vagus Nerve
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