Laser nephelometric evaluation of albumin, IgG and α2-macroglobulin: applications to the study of alterations of the blood-brain barrier
Abstract
Cerebrospinal fluid and serum levels of albumin, immunoglobulin G and alpha 2-macroglobulin were determined by laser nephelometer in various pathological conditions: Guillain-Barré syndrome amyotrophic lateral sclerosis, lumbar disc herniation. These proteins are different due to their molecular weight, spacial conformation, CSF and serum concentrations and their CSF/serum quotient reflects the status of the blood-brain barrier. In the subjects group comparisons, albumin quotient and IgG quotient show a significant differentiations. The linear regression of albumin quotient compared to alpha 2-macroglobulin quotient behaves differently in the individual groups. The protein CSF/serum quotients are helpful in distinguishing the causes of alterations in the blood-brain barrier.
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Increased Qalb values were found in 40% of all studied amyotrophic lateral sclerosis cases (55/138 from 4 independent studies).
“increased Qalb values were found in 40% of all studied ALS cases (i.e., 55/138 from 4 independent studies) (23, 79, 407, 525)”
From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [407]
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Zlokovic, B. V. (2008) · Neuron · doi:10.1016/j.neuron.2008.01.003 · Cited by 3,280 · see citing works
Blood-Brain Barrier: From Physiology to Disease and Back
Sweeney, M. D., Zhao, Z., Montagne, A., Nelson, A. R., & Zlokovic, B. V. (2019) · Physiological Reviews · doi:10.1152/physrev.00050.2017 · Cited by 2,294 · see citing works
The blood-brain barrier in aging and neurodegeneration
Knox, E. G., Aburto, M. R., Clarke, G., Cryan, J. F., & O’Driscoll, C. M. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01511-z · Cited by 738 · see citing works
- Authors
- Meucci, G., Rossi, G., Bettini, R., Montanaro, D., Gironelli, L., Voci, L., & Bianchi, F.
- Affiliations
- University of Pisa (IT)
- Istituto di Fisiologia Clinica (IT)
- Corresponding author
- Meucci, Giuseppe
- Venue
- Journal of the Neurological Sciences
- Publisher
- Elsevier BV
- Published
- 1993-08
- Volume
- 118
- Issue
- 1
- Pages
- 73-78
- ISSN
- 0022-510X (ISSN-L)
- OpenAlex
- W2020550032
- Cited by
- 26
- References
- 0
- Citations by year
- 2024: 2 · 2023: 1 · 2022: 2 · 2021: 4 · 2020: 1 · 2019: 1 · 2018: 1 · 2013: 1 · 2012: 5
- FWCI
- 0.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the Neurological Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Cerebrospinal fluid and hydrocephalus
- Health Sciences › Medicine › Physiology › Clinical Laboratory Practices and Quality Control
- Keywords
- blood-brain barrier, cerebrospinal fluid, serum albumin, IgG, alpha2-macroglobulin, Guillain-Barré syndrome, amyotrophic lateral sclerosis, lumbar disc herniation, laser nephelometry
- MeSH terms
- Adolescent, Adult, Aged, Albumins, alpha-Macroglobulins, Amyotrophic Lateral Sclerosis, Blood-Brain Barrier, Brain Chemistry, Cerebrospinal Fluid Proteins, Female, Humans, Immunoglobulin G, Intervertebral Disc Displacement, Lasers, Male, Middle Aged, Nephelometry and Turbidimetry, Polyradiculoneuropathy, Regression Analysis
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