The logical analysis of continuous, non-linear biochemical control networks
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The basic McCulloch-Pitts design is common to many other living systems, including gene regulatory networks, immune networks, collective intelligence or some aneural systems, such as quorum-sensing decisions in microbial communities.
“Interestingly, the basic McCulloch–Pitts design is common to many other living systems, including gene regulatory networks [256–259], immune networks [260–262], collective intelligence [263–267] or some aneural systems, such as quorum-sensing decisions in microbial communities, where an explicit equivalence has been defined [268].”
From Fundamental constraints to the logic of living systems (2024) · cites this paper as [256]
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Hopfield, J. J. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.10.3088 · Cited by 6,918 · see citing works
Modelling and analysis of gene regulatory networks
Karlebach, G., & Shamir, R. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2503 · Cited by 1,296 · see citing works
Bifurcation dynamics in lineage-commitment in bipotent progenitor cells
Huang, S., Guo, Y.-P., May, G., & Enver, T. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.02.036 · Cited by 560 · see citing works
Thomas, R., & Kaufman, M. (2001) · Chaos: An Interdisciplinary Journal of Nonlinear Science · doi:10.1063/1.1349893 · Cited by 242 · see citing works
The large scale structure and dynamics of gene control circuits
Kauffman, S. (1974) · Journal of Theoretical Biology · doi:10.1016/s0022-5193(74)80037-8 · Cited by 232 · see citing works
Self-citationThe Powerful Law of the Power Law and Other Myths in Network Biology
Lima-Mendez, G., & van Helden, J. (2009) · Molecular BioSystems · doi:10.1039/b908681a · Cited by 210 · see citing works
Fundamental constraints to the logic of living systems
Solé, R., Kempes, C. P., Corominas-Murtra, B., De Domenico, M., Kolchinsky, A., Lachmann, M., Libby, E., Saavedra, S., Smith, E., & Wolpert, D. (2024) · Interface Focus · doi:10.1098/rsfs.2024.0010 · Cited by 34 · see citing works
“Interestingly, the basic McCulloch–Pitts design is common to many other living systems, including gene regulatory networks [256–259], immune networks [260–262], collective intelligence [263–267] or some aneural systems, such as quorum-sensing decisions in microbial communities, where an explicit…”
BackgroundRelating simulation studies by provenance—Developing a family of Wnt signaling models
Budde, K., Smith, J., Wilsdorf, P., Haack, F., & Uhrmacher, A. M. (2021) · PLOS Computational Biology · doi:10.1371/journal.pcbi.1009227 · Cited by 23 · see citing works
“, using the Systems Biology Graphical Notation (SBGN) [70] or a Boolean network diagram [71]) or informal way.”
MethodEvolution of Brains and Computers: The Roads Not Taken
Solé, R., & Seoane, L. F. (2022) · Entropy · doi:10.3390/e24050665 · Cited by 14 · see citing works
- Authors
- Glass, L., & Kauffman, S. A.
- Affiliations
- University of Rochester (US)
- University of Chicago (US)
- Venue
- Journal of Theoretical Biology
- Publisher
- Elsevier BV
- Published
- 1973-04
- Volume
- 39
- Issue
- 1
- Pages
- 103-129
- ISSN
- 0022-5193 (ISSN-L)
- OpenAlex
- W2031369606
- Cited by
- 940
- References
- 0
- Citations by year
- 2026: 10 · 2025: 19 · 2024: 32 · 2023: 23 · 2022: 33 · 2021: 24 · 2020: 27 · 2019: 25 · 2018: 45 · 2017: 35 · 2016: 33 · 2015: 28 · 2014: 38 · 2013: 52 · 2012: 47
- FWCI
- 1.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Theoretical Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
- Physical Sciences › Mathematics › Geometry and Topology › Advanced Differential Equations and Dynamical Systems
- Physical Sciences › Computer Science › Computer Networks and Communications › Nonlinear Dynamics and Pattern Formation
- Keywords
- logical analysis, qualitative dynamics, steady state, phase equilibria, feedback oscillators, bistable switch, nonlinear dynamics, parameter invariance
- MeSH terms
- Cell Differentiation, Feedback, Logic, Metabolism, Models, Biological, Molecular Biology, Periodicity
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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