Phencyclidine produces aggressive behavior in rapid eye movement sleep-deprived rats
Abstract
This study examined effects of acute doses of phencyclidine (PCP; 0.025, 0.05, 0.10, and 0.20 mg/kg intraperitoneally) on intra-specific aggressive behavior and muricide in normal rats and rats deprived of rapid eye movement (REM) sleep. Dose-related changes in intra-specific aggression and muricide occurred in REM sleep-deprived rats only. Dose-response curves are inverted-U shaped with the .05 mg/kg dose producing increases in aggression. Intra-specific aggression and muricide may serve as models of PCP-induced aggression in humans.
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There is a report of increased aggression in the form of phencyclidine-induced muricide after sleep deprivation.
“there is also a report of increased aggression in the form of phencyclidine-induced muricide after sleep deprivation.72,73”
From Sleep Deprivation and Circadian Disruption (2015) · cites this paper as [72]
Sleep deprivation is associated with increases in fighting behavior after deprivation of REM sleep, and increased aggression in the form of muricide after phencyclidine administration after sleep deprivation.
“Sleep deprivation has also been associated with increases in fighting behavior after deprivation of rapid eye movement (REM) sleep;37 there is also a report of increased aggression in the form of muricide after phencyclidine administration after sleep deprivation.38”
From Protective and damaging effects of stress mediators: central role of the brain (2006) · cites this paper as [38]
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References 18 · Cited by 26
- Authors
- Musty, R. E., & Consroe, P. F.
- Affiliations
- University of Arizona (US)
- Corresponding author
- Consroe, Paul F.
- Venue
- Life Sciences
- Publisher
- Elsevier BV
- Published
- 1982-05
- Volume
- 30
- Issue
- 20
- Pages
- 1733-1738
- ISSN
- 0024-3205 (ISSN-L)
- OpenAlex
- W2039049874
- Cited by
- 26
- References
- 18
- Citations by year
- 2022: 1 · 2019: 1 · 2018: 1 · 2015: 1 · 2014: 2 · 2012: 1
- FWCI
- 0.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Life Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- phencyclidine, PCP, muricide, REM sleep deprivation, aggression, dose-response relationship, NMDA receptor antagonists
- MeSH terms
- Aggression, Animals, Dose-Response Relationship, Drug, Humans, Male, Phencyclidine, Rats, Inbred Strains, Sleep Deprivation, Sleep, REM, Substance-Related Disorders, Mice, Rats
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