Evidence that nitric oxide modulates food intake in mice
Abstract
Nitric oxide (NO) may be an intercellular modulator within the central nervous system. L-arginine, which results in NO synthesis, increased food intake in mice while the inhibitor of NO synthesis, L-NG-nitro arginine (L-NO Arg) inhibited food intake in food deprived mice. L-arginine, but not D-arginine, partially reversed the inhibitory effect of L-NO Arg on food intake. These findings suggest the possibility that NO may be a physiological modulator of food intake and that the possibility of exploring the utility of L-NO arg in the treatment of obesity should be explored.
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In rodents, L-arginine increases food intake and NOS inhibitors decrease food intake.
“In rodents, L-arginine was shown to increase, and NOS inhibitors to decrease, food intake [155, 251-254].”
From Regulation of obesity and insulin resistance by nitric oxide (2014) · cites this paper as [251]
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References 18 · Cited by 188
- Authors
- Morley, J. E., & Flood, J. F.
- Affiliations
- St. Louis VA Medical Center (US)
- ORCID
- Morley, John E.
- Venue
- Life Sciences
- Publisher
- Elsevier BV
- Published
- 1991-01
- Volume
- 49
- Issue
- 10
- Pages
- 707-711
- ISSN
- 0024-3205 (ISSN-L)
- OpenAlex
- W2020876673
- Cited by
- 188
- References
- 18
- Citations by year
- 2026: 2 · 2024: 2 · 2023: 2 · 2022: 5 · 2021: 5 · 2020: 1 · 2019: 3 · 2018: 2 · 2017: 3 · 2016: 2 · 2015: 2 · 2014: 8 · 2013: 4 · 2012: 4
- FWCI
- 4.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Life Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Pharmacology › Pharmacology and Obesity Treatment
- Keywords
- nitric oxide, dietary intake, L-arginine, L-NG-nitroarginine, food deprivation, obesity treatment, central nervous system modulation, D-arginine
- MeSH terms
- Animals, Arginine, Feeding Behavior, Male, Nitric Oxide, Stereoisomerism, Mice
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