The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Modulation of the NMDA receptor by polyamines
Open accessAbstract
Results of recent biochemical and electrophysiological studies have suggested that a recognition site for polyamines exists as part of the NMDA receptor complex. This site appears to be distinct from previously described binding sites for glutamate, glycine, Mg++,Zn++, and open-channel blockers such as MK-801. The endogenous polyamines spermine and spermidine increase the binding of open-channel blockers and increase NMDA-elicited currents in cultured neurons. These polyamines have been termed agonists at the polyamine recognition site. Studies of the effects of natural and synthetic polyamines on the binding of [3H]MK-801 and on NMDA-elicited currents in cultured neurons have led to the identification of compounds classified as partial agonists, antagonists, and inverse agonists at the polyamine recognition site. Polyamines have also been found to affect the binding of ligands to the recognition sites for glutamate and glycine. However, these effects may be mediated at a site distinct from that at which polyamines act to modulate the binding of open-channel blockers. Endogenous polyamines may modulate excitatory synaptic transmission by acting at the polyamine recognition site of the NMDA receptor. This site could represent a novel therapeutic target for the treatment of ischemia-induced neurotoxicity, epilepsy, and neurodegenerative diseases.
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Cites
Morris, R. G. M., Anderson, E., Lynch, G. S., & Baudry, M. (1986) · Nature · doi:10.1038/319774a0 · Cited by 3,640
MacDermott, A. B., Mayer, M. L., Westbrook, G. L., Smith, S. J., & Barker, J. L. (1986) · Nature · doi:10.1038/321519a0 · Cited by 1,835
The current excitement in long term potentiation
Nicoll, R. A., Kauer, J. A., & Malenka, R. C. (1988) · Neuron · doi:10.1016/0896-6273(88)90193-6 · Cited by 535
Cited by
Developmental switch in the expression of NMDA receptors occurs in vivo and in vitro
Williams, K., Russell, S. L., Shen, Y. M., & Molinoff, P. B. (1993) · Neuron · doi:10.1016/0896-6273(93)90317-k · Cited by 455
Self-citationGlutamate and Parkinson’s disease
Blandini, F., Porter, R. H. P., & Greenamyre, J. T. (1996) · Molecular Neurobiology · doi:10.1007/bf02740748 · Cited by 323
New perspectives in glutamate and anxiety
Riaza Bermudo-Soriano, C., Perez-Rodriguez, M. M., Vaquero-Lorenzo, C., & Baca-Garcia, E. (2012) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2011.04.010 · Cited by 207
Rossetti, Z. L., Carboni, S., & Fadda, F. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00250-x · Cited by 69
GlutamateNMDA receptor NR1 subunit mRNA expression in Alzheimer's disease
Hynd, M. R., Scott, H. L., & Dodd, P. R. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00409.x · Cited by 66
Metadata
- Authors
- Williams, K., Romano, C., Dichter, M. A., & Molinoff, P. B.
- Venue
- Life Sciences
- Publisher
- Elsevier BV
- Published
- 1991
- Volume
- 48
- Issue
- 6
- Pages
- 469-498
- ISSN
- 0024-3205 (ISSN-L)
- OpenAlex
- W2034377493
- Cited by
- 338
- References
- 3
- FWCI
- 13.81
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Williams, K., Romano, C., Dichter, M. A., & Molinoff, P. B. (1991). Modulation of the NMDA receptor by polyamines. Life Sciences. https://doi.org/10.1016/0024-3205(91)90463-l
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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