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Cited by 18Pancreatic function and diabetesAdrenal Hormones and DisordersGrowth Hormone and Insulin-like Growth Factors

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Metabolic interactions of glucagon and cortisol in man—Studies with somatostatin

Gill, A., Johnston, D.G., Ørskov, H., Batstone, G.F., Alberti, K.G.M.M.·1982·Metabolism
DOI 10.1016/0026-0495(82)90104-4
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Abstract

The metabolic response to pathophysiologic concentrations of glucagon, induced by glucagon infusion, has been examined in normal man before and after 36-60 hr hypercortisolaemia, induced by administration of tetracosactrin-depot. Glucagon alone increased serum insulin levels twofold but blood glucose was unaltered. Plasma NEFA and blood ketone body concentrations were decreased by glucagon infusion. Tetracosactrin produced a threefold rise in serum cortisol levels and caused mild fasting hyperglycemia and hyperinsulinaemia. Subsequent glucagon infusion had no effect on circulating insulin, glucose, NEFA or ketone body concentrations. Simultaneous infusion of somatostatin, to produce partial insulin-deficiency, unmasked a hyperglycemic action of glucagon (+ 3.8 +/- 0.2 mmol/l at 90 min, p less than 0.02). This glucagon-induced rise in blood glucose was diminished by prior tetracosactrin administration. Tetracosactrin revealed a mild lipolytic action of glucagon in partial insulin deficiency, not apparent in the euadrenal state. Glucagon was equally hyperketonemic during somatostatin infusion before and after tetracosactrin. Thus the hyperglycemic and hyperketonemic actions of glucagon at pathophysiologic levels are restricted to insulin deficiency. Hypercortisolaemia reveals a lipolytic action of glucagon in insulin-deficient man but does not potentiate the hyperglycemic or hyperketonemic effects.

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References 43 · Cited by 18

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Metadata

Authors
Gill, A., Johnston, D. G., Ørskov, H., Batstone, G. F., & Alberti, K. G. M. M.
ORCID
Johnston, D.G.
Venue
Metabolism
Publisher
Elsevier BV
Published
1982-04
Volume
31
Issue
4
Pages
305-311
ISSN
0026-0495 (ISSN-L)
DOI
10.1016/0026-0495(82)90104-4
OpenAlex
W2166204541
Cited by
18
References
43
Citations by year
2013: 2 · 2012: 1
FWCI
3.87
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
Keywords
glucagon, cortisol, somatostatin, hypercortisolism, tetracosactrin, insulin deficiency, hyperglycemia, hyperketonemia, lipolysis, free fatty acids
MeSH terms
Adult, Blood Glucose, Cosyntropin, Drug Synergism, Fatty Acids, Nonesterified, Glucagon, Humans, Hydrocortisone, Insulin, Ketone Bodies, Male, Somatostatin

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