CoChat
Sign Up
Cited by 21

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Brain lipoprotein lipase is responsive to nutritional and hormonal modulation

Gavin, Laurence A., Cavalieri, Ralph R., Moeller, Marie, McMahon, Francis A., Castle, James N., Gulli, Rocco·1987·Metabolism
DOI 10.1016/0026-0495(87)90124-7
Open this paper in CoChat — free account

Abstract

Functional lipoprotein lipase activity was recently described in rat brain. The present study was performed to further characterize the biologic significance of brain lipoprotein lipase (heparin releasable component) and elucidate regulatory factors. Comparative studies were performed on tissue (brain, adipose, and heart) heparin releasable lipoprotein lipase in the fasted and diabetic (streptozotocin 100 mg/kg BW IP) rat. Both fasting (96 hours) and diabetes (ten days) significantly decreased brain (cortical) (P less than .05) and adipose (epididymal fat pad) (P less than .001) lipoprotein lipase activity. In contrast, heart muscle enzyme activity was significantly increased (P less than .001) in response to fasting and diabetes. Refeeding (Purina chow 96 hours) and insulin replacement (96 hours) reversed these changes in tissue lipoprotein lipase consequent to fasting and diabetes, respectively. There was a positive correlation between the changes in serum insulin concentration and adipose lipoprotein lipase, but there was no correlation between this parameter and brain or heart lipoprotein lipase. In addition, although T3 therapy normalized the low T3 state associated with both fasting and diabetes, it had no effect on the enzyme activity in the studied tissues. However, subsequent studies demonstrated that hypothyroidism (2 weeks post thyroidectomy) significantly decreased brain lipoprotein lipase activity (P less than .001) and increased both the adipose (P less than .02…

Overview

Integrity signals

Registry

Crossref · 10.1016/0026-0495(87)90124-7

Cites

1 of 1 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Flagged first, then by citations

Show all 1 references

Research works printed but not linked: 16

  1. Nisson-Ehle, 1980, Lipolytic enzyme and plasma lipoprotein metabolism, Annu Rev Biochem, 49, 667, 10.1146/annurev.bi.49.070180.003315 · DOI
  2. Noruma, 1984, The effects of streptozotocin diabetes on tissue specific lipase activities in the rat, Lipids, 19, 594, 10.1007/BF02534717 · DOI
  3. Gavin, 1985, Modulation of adipose lipoprotein lipase by thyroid hormone and diabetes: The significance of the low T3 state, Diabetes, 34, 1266, 10.2337/diab.34.12.1266 · DOI
  4. Redgrave, 1977, Clearance of chylomicron triacglycerol and cholesterylester from the plasma of streptozotocin-induced diabetic and hypercholestrolemic hypothyroid rats, Metabolism, 26, 493, 10.1016/0026-0495(77)90093-2 · DOI
  5. Pykalisto, 1974, The tissue distribution of triaclyglycerol lipase, monacylglycerol lipase and phospholipase in fasted and fed rats, Biochim Biophys Acta, 369, 254, 10.1016/0005-2760(74)90256-2 · DOI
  6. Gavin, 1980, Sequential deiodination of thyroxine to 3,3′-diiodothyronine via 3,5,3′-triiodothyronine and 3,3′–5′-triiodothyronine in rat liver homogenate: The effect of fasting versus glucose feeding, J Biol Chem, 254, 49, 10.1016/S0021-9258(19)86261-0 · DOI
  7. Grodsky, 1961, Comparative binding of beef and human insulin to insulin antibodies produced in man and guinea pig, J Clin Invest, 40, 799, 10.1172/JCI104313 · DOI
  8. Gavin, 1983, The mechanism of recovery of hepatic T4-5′-deiodinase during glucose-refeeding: Role of glucose and insulin, Metabolism, 32, 543, 10.1016/0026-0495(83)90023-9 · DOI
  9. Spayd, 1978, Multilayer film elements for clinical analysis, Clin Chem, 24, 1343, 10.1093/clinchem/24.8.1343 · DOI
  10. Elkeles, 1977, The effect of fasting and streptozotocin diabetes on hepatic triglyceride lipase activity in the rat, Diabetes, 26, 58, 10.2337/diab.26.1.58 · DOI
  11. Chen, 1980, Dissociation between plasma triglyceride concentration and tissue lipoprotein lipase deficiency in insulin-deficient rats, Diabetes, 29, 643, 10.2337/diab.29.8.643 · DOI
  12. Hansson, 1983, Influence of nutritional state on lipoprotein lipase activities in the hypothyroid rat, Biochim Biophys Acta, 753, 364, 10.1016/0005-2760(83)90060-7 · DOI
  13. Ashby, 1978, Post-translational regulation of lipoprotein lipase activity in adipose tissue, Biochem J, 176, 865, 10.1042/bj1760865 · DOI
  14. Edgar, 1982, Phospholipase activities of rat brain cytosol: Occurrence of phospholipase c activity with phosphatidylcholine, Biochim Biophys Acta, 711, 224, 10.1016/0005-2760(82)90030-3 · DOI
  15. Volpe, 1972, Fatty acid synthase of brain: Development and influence of nutritional and hormonal factors and comparisons with liver enzyme, J Neurochem, 19, 737, 10.1111/j.1471-4159.1972.tb01389.x · DOI
  16. Rosseau, 1983, Subcellular distribution of diacylglycerol lipase in rat and mouse brain, Neurol Chem Res, 8, 417

Cited by

Sorted by citations

See all 21

Metadata

Authors
Gavin, L. A., Cavalieri, R. R., Moeller, M., McMahon, F. A., Castle, J. N., & Gulli, R.
Venue
Metabolism
Publisher
Elsevier BV
Published
1987-10
Volume
36
Issue
10
Pages
919-924
ISSN
0026-0495
DOI
10.1016/0026-0495(87)90124-7
Cited by
21
References
1
Language
en
Licence

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review