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Regulation of hepatic glucose output during moderate exercise in non-insulin-dependent diabetes
Abstract
In normal subjects during moderate exercise there is a strong negative correlation between plasma glucose and hepatic glucose output (HGO) suggesting a negative feedback regulation of HGO by plasma glucose. Little information is available about HGO responses to exercise in non-insulin-dependent diabetes mellitus (NIDDM). To determine whether the same feedback relationship is operative, we have compared the glucose turnover responses to moderate exercise (50% Vo2max for 60 minutes) of nonobese non-insulin-dependent diabetic subjects (NIDDM, n = 7) with a group of age-matched controls (n = 5). Glucose turnover responses to exercise in NIDDM were heterogeneous. Plasma glucose showed sustained falls, no change, or sustained rises in different individuals. Similarly, HGO responses ranged from undetectable to responses comparable to those of normal subjects. The mean integrated HGO response in NIDDM was significantly reduced compared with controls (11 +/- 6 [SEM] v 33 +/- 7 mmol/h/70 kg, P less than .05); mean glucose utilization response was also reduced but not significantly different from controls (NIDDM 18 +/- 5 v control 35 +/- 6). In NIDDM there was no significant feedback-control relationship between plasma glucose and HGO (r = -0.20, P = NS) in contrast to controls (r = -0.87, P less than .01). We conclude that feedback control of HGO by plasma glucose during moderate exercise is impaired in NIDDM. This impairment may be due to defective nonpancreatic glucoregulatory mechan…
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“The finding of no change in glucose production in response to exercise in the postprandial state is in line with the facts that often an increase in hepatic glucose production is not seen with exercise when insulin levels are elevated [1, 7, 22, 23] and that exercise does not change glucose absorption from the gut [24].”
From The effect of moderate exercise on postprandial glucose homeostasis in NIDDM patients (1997) · cites this paper as [23]
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References 24 · Cited by 34
Research works printed but not linked: 25
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Metadata
- Authors
- Jenkins, A. B., Furler, S. M., Bruce, D. G., & Chisholm, D. J.
- Affiliations
- Garvan Institute of Medical Research (AU)
- Venue
- Metabolism
- Publisher
- Elsevier BV
- Published
- 1988-10
- Volume
- 37
- Issue
- 10
- Pages
- 966-972
- ISSN
- 0026-0495 (ISSN-L)
- OpenAlex
- W2081459755
- Cited by
- 34
- References
- 24
- Citations by year
- 2026: 1 · 2016: 1 · 2014: 2 · 2012: 1
- FWCI
- 0.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Keywords
- hepatic glucose production, type 2 diabetes, moderate-intensity exercise, glucose turnover, plasma glucose, negative feedback regulation, glucose utilization, glucoregulation
- MeSH terms
- Insulin Secretion, Aged, Diabetes Mellitus, Type 2, Feedback, Glucose, Humans, Insulin, Liver, Male, Middle Aged, Exercise
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