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The initial lymphatics as sensors of interstitial fluid volume
Abstract
Lymphatic luminal pressure and interstitial fluid pressure (IFP) were measured simultaneously in the bat's wing with two servo-null micropressure systems during interstitial fluid volume expansion induced by direct interstitial infusion. Lymphatic baseline pressure, pulsatile pressure, and IFP were elevated by the interstitial infusion. Transmural pressure gradients occurred only transiently. The increased lymphatic pulsatile pressure was not dependent upon the transmural pressure gradient but remained elevated as long as the increased interstitial fluid volume (IFV) was maintained. The results suggest that lymphatic pumping capacity during edema is modulated by IFV rather than IFP and that this mechanism may play an important role in the regulation of interstitial hydration. A mechanism whereby the initial lymphatics may directly sense and control IFV is proposed based upon physiological and anatomical data.
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“Subsequent studies employing simultaneous measurements of pressures in the lymphatic capillary lumen and the interstitium showed that a favorable hydrostatic pressure gradient for reabsorption occurs transiently during the lymphatic contraction cycle when intraluminal pressure falls below interstitial pressure (30); this gradient provides the predominant driving force for reabsorption.”
From Transport and Immune Functions of the Lymphatic System. (2025) · cites this paper as [30]
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No references could be resolved yet.
Research works printed but not linked: 8
- Aukland, 1981, Interstitial fluid volume local regulatory mechanisms, Physiol. Rev., 61, 556, 10.1152/physrev.1981.61.3.556 · DOI
- Chen, 1976, Interaction of capillary, interstitial, and lymphatic forces in the canine hindpaw, Circ. Res., 39, 245, 10.1161/01.RES.39.2.245 · DOI
- Guyton, 1965, Interstitial fluid pressure. 11. Pressure-volume curves of interstitial space, Circ. Res., 16, 452, 10.1161/01.RES.16.5.452 · DOI
- Hargens, 1977, Contractile stimuli in collecting lymph vessels, Amer. J. Physiol., 233, H57
- Leak, 1970, Electron microscopic observations on lymphatic capillaries and the structural components of the connective tissue-lymph interface, Microvasc. Res., 2, 361, 10.1016/0026-2862(70)90031-2 · DOI
- Skalak, 1984, New morphological evidence for a mechanism of lymph formation in skeletal muscle, Microvasc. Res., 28, 95, 10.1016/0026-2862(84)90032-3 · DOI
- Wiedeman, 1973, Preparation of the bat wing for in vivo microscopy, Microvasc. Res., 5, 417, 10.1016/0026-2862(73)90058-7 · DOI
- Zweifach, 1979, The interstitial-lymphatic flow system, Vol. 18, 215
Cited by
Sorted by citations
Transport and Immune Functions of the Lymphatic System.
Davis, M. J., Zawieja, S. D., & King, P. D. (2025) · Annual Review of Physiology · doi:10.1146/annurev-physiol-022724-104908 · Cited by 42
Metadata
- Authors
- Hogan, R. D., & Unthank, J. L.
- Affiliations
- Indiana University Indianapolis (US)
- Venue
- Microvascular Research
- Publisher
- Elsevier BV
- Published
- 1986-05
- Volume
- 31
- Issue
- 3
- Pages
- 317-324
- ISSN
- 0026-2862 (ISSN-L)
- OpenAlex
- W2063305546
- Cited by
- 40
- References
- 0
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 1 · 2022: 1 · 2021: 1 · 2017: 2 · 2012: 2
- FWCI
- 1.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Microvascular Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Lymphatic System and Diseases
- Health Sciences › Medicine › Surgery › Lymphatic Disorders and Treatments
- Health Sciences › Medicine › Infectious Diseases › Parasitic Diseases Research and Treatment
- Keywords
- initial lymphatics, interstitial fluid volume, interstitial fluid pressure, lymphatic pressure, edema, bat wings
- MeSH terms
- Animals, Chiroptera, Extracellular Space, Lymph, Pressure
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