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Down-regulation of β-adrenergic receptors following repeated injections of desmethylimipramine: Permissive role of serotonergic axons
Open accessAbstract
The injection of desmethylimipramine (DMI) twice daily for 3 weeks reduced the density of beta-adrenergic receptor recognition sites located in crude synaptic membranes prepared from the cortex and hippocampus and attenuated the stimulation of the membrane-bound adenylate cyclase by isoproterenol. Both actions were abolished if prior to treatment with desmethylimipramine the serotonergic axons were destroyed by an intraventricular injection of 5,7-dihydroxytryptamine. These results show that the down-regulation of beta-adrenergic receptors elicited by repeated injections of desmethylimipramine occurs only if the serotonergic axons are intact.
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Cited by
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Overstreet, D. H. (1993) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(05)80230-1 · Cited by 369
Nelson, J. C. (1991) · Archives of General Psychiatry · doi:10.1001/archpsyc.1991.01810280019002 · Cited by 294
Metadata
- Authors
- BRUNELLO, N., BARBACCIA, M., CHUANG, D., & COSTA, E.
- Venue
- Neuropharmacology
- Publisher
- Elsevier BV
- Published
- 1982-11
- Volume
- 21
- Issue
- 11
- Pages
- 1145-1149
- ISSN
- 0028-3908 (ISSN-L)
- OpenAlex
- W1964888274
- Cited by
- 188
- References
- 0
- FWCI
- 9.82
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Down-regulation of β-adrenergic receptors following repeated injections of desmethylimipramine: Permissive role of serotonergic axons. https://app.cochat.ai/papers/10.1016/0028-3908(82)90172-1
- The paper
- BRUNELLO, N., BARBACCIA, M., CHUANG, D., & COSTA, E. (1982). Down-regulation of β-adrenergic receptors following repeated injections of desmethylimipramine: Permissive role of serotonergic axons. Neuropharmacology. https://doi.org/10.1016/0028-3908(82)90172-1
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
